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Molecular Diagnostics

Image: The LabTurbo 48 compact system can fully automate DNA/RNA extraction of up to 48 samples in 90 minutes (Photo courtesy of Taigen Bioscience).

Commercial Molecular Assay Validated for Dengue Virus Outbreak

Dengue virus (DENV) is a member of the viral genus Flavivirus (family Flaviviridae) that is transmitted by mosquitos, causing endemic and epidemic outbreaks in tropical and subtropical areas. More...
28 Oct 2016
Image: A histopathology of a moderately differentiated adenocarcinoma of colon showing a glandular configuration, but the glands are irregular and very crowded. Many of them have lumens containing bluish mucin (Photo courtesy of Raul Gonzalez MD).

Blood Test for Colorectal Cancer Recurrence Proves Highly Sensitive

When diagnosed early, before cancer has spread, the relative five-year survival rate for colorectal cancer (CRC) is 90%, but only approximately four out of 10 CRC cases are detected early. More...
27 Oct 2016
Image: A Petri dish with Group A Streptococcus-inoculated trypticase soy agar containing 5% defibrinated sheep\'s blood (Photo courtesy of Richard R. Facklam, PhD).

DNA-Based Analysis Detects Group A Streptococcus

As an exclusively human pathogen, Group A Streptococcus (GAS; Streptococcus pyogenes) is spread in the community through direct human-to-human transmission and GAS can also colonize a healthy host without any apparent clinical signs or symptoms. More...
27 Oct 2016
Image: The discovery of two classes of Crohn\'s has implications for scientists to deliver more targeted treatments (Photo courtesy of MNT).

Gene Activity Mapping Points to Two Subtypes of Crohn's Disease

Gene activity studies have found that there are two clinically relevant forms of Crohn's disease that are defined by molecular signatures that are not linked to tissue sampling location, patient age, or treatment status. More...
26 Oct 2016
Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Tests Identified Cell-Free Tumor DNA Mutations

The feasibility of using cell-free circulating tumor DNA (ctDNA) next-generation sequencing (NGS) from liquid biopsies as a complement or alternative to tissue NGS has been evaluated. More...
20 Oct 2016
Image: A histopathology of non-alcoholic steatohepatitis (NASH) in a liver biopsy (Photo courtesy of SPL).

Simple Blood Test Vastly Improves Severe Liver Disease Detection

A new non-invasive method of predicting the risk of developing a severe form of liver disease could ensure patients receive early and potentially life-saving medical intervention before irreversible damage is done. More...
19 Oct 2016
Image: A diagram of mechanisms of RNA-Mediated DNA Rearrangement. (A) Chimeric RNAs act as repair templates for double-strand DNA breakage. (B) Chimeric RNAs act as scaffolds to bring two genomic loci into proximity, which might promote breakage and fusion between the two gene loci (Photo courtesy of the University of Virginia).

Strange Chimeras Defy Scientific Understanding of Human Genetics

The human genome is far more complex than thought, with genes functioning in an unexpected fashion that scientists have wrongly assumed must indicate cancer as gene fusions and their encoded products fusion ribonucleic acids (RNAs) and proteins are viewed as one of the hallmarks of cancer. More...
18 Oct 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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