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Clinical Chemistry

Image: The SP300 electrochemistry system (Photo courtesy of BioLogic Science Instruments).

Chemosensor Detects Cancer Biomarker Neopterin

A procedure has been established of molecular imprinting; a synthetic polymer receptor for the neopterin cancer biomarker was devised and used as a recognition unit of a potentiometric chemosensor. More...
02 Jun 2016
Image: Brain Natriuretic Peptide (BNP) levels in patients with and without sarcopenia. Risk of heart failure is higher in patients with sarcopenia (Photo courtesy of Dr. Yasuhiro Izumiya).

Simple Sarcopenia Screening Test Found to Predict Heart Failure Severity

Researchers have shown that the simple screening method originally developed to diagnose sarcopenia can be used, instead of CT or MRI, to quickly and easily predict severity of heart failure disease. They also found that the predictive capabilities of the brain natriuretic peptide (BNP) lab test for heart function can be further improved if coupled with a patient's sarcopenia test score. More...
31 May 2016
DIASOURCE (A Biovendor Company)
Image: A new electronic biosensor successfully detects the enzyme glutathione S-transferase (GST), linked to Parkinson\'s, Alzheimer\'s, and breast cancer, among other diseases (Photo courtesy of Brazilian National Nanotechnology Laboratory).

Bioelectronic Device Detects Marker Linked to Neurodegenerative Diseases and Cancer

Researchers have developed a inexpensive transistor sensor for detection of biomolecules and other substances. Their first biosensor successfully detects the enzyme glutathione S-transferase (GST), linked to Parkinson's, Alzheimer's and breast cancer, among other diseases. The team is also developing an innovative paper-based electronic sensor to lower the cost even further. More...
31 May 2016
Image: The Synergy multimode microplate reader ((Photo courtesy of BioTek Instruments).

Blood Analyses Predict Delirium Risk In Older Surgical Patients

Delirium, or sudden severe confusion due to rapid changes in brain function that can occur with physical or mental illness, affects 15% to 53% of older surgical patients and has been linked with longer hospital stays, greater postoperative complications, and higher rates of discharge to nursing homes. More...
26 May 2016
Image: Clinical manifestation of Homozygous Familial Hypercholesterolemia, interdigital xanthoma (Photo courtesy of the National Organization for Rare Disorders).

New Gene Associated With Familial High Cholesterol

The gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol has been revealed. Familial hypercholesterolemia is the most common genetic disorder leading to premature death, found in 1 in 200 people. More...
26 May 2016
Image: A bone marrow aspirate biopsy of a patient with Gaucher Disease; the cytoplasm has wrinkled tissue paper appearance (Photo courtesy of the American Society of Hematology).

Elevated Chitotriosidase Differentially Diagnoses Lysosomal Storage Disorders

Plasma chitotriosidase originates from activated macrophages and is reported to be elevated in many Lysosomal Storage Disorders. Measurement of this enzyme’s activity has been an available tool for monitoring therapy of Gaucher disease. More...
25 May 2016
Image: The lab-on-a-chip device integrates a fiber optic biosensor with a microfluidic chip and detects glucose levels from droplets of sweat. It is shown here next to a Hong Kong dollar, which is the same size as the USD coin (Photo courtesy of Dr. A. Ping Zhang).

Microfluidic Chip Developed For Ultrasensitive Glucose Detection

Highly sensitive and rapid detection of blood glucose is a diagnostic necessity in medicine as, for instance, lack of insulin and too much blood sugar are two main causes of diabetes, both of which can be detected by measuring blood glucose. More...
18 May 2016
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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