We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Novel Analytical Method Tracks Progression of Autoimmune Diseases

By LabMedica International staff writers
Posted on 28 Feb 2025

Patients with autoimmune diseases often have lifelong contact with doctors and hospitals. More...

The typical patient diagnosed is a woman in her fifties and the disease requires lifelong treatment. But it is important to ensure the medication dosage is neither too high nor too low. A dosage that is too low causes joint deformity, too high causes side effects and the risk of complications. Tracking disease progression is crucial for ensuring optimal treatment. Researchers have now developed a novel analytical method for tracking disease progression in patients that shows great potential for healthcare implementation.

A team of researchers from Aarhus University (Aarhus, Denmark) has developed a method that offers doctors quicker and easier access to valuable information regarding disease progression. Published in the Journal of Translational Autoimmunity, their study introduces a promising biomarker to monitor disease activity in rheumatoid arthritis, and potentially other autoimmune conditions. In previous research, the team highlighted the importance of monitoring large proteins in blood samples from patients with conditions like Lupus and Alzheimer’s to track disease progression. Their latest work presents an analytical approach with strong potential for large-scale clinical applications. In the current study, the team analyzed blood and synovial fluid samples from rheumatoid arthritis patients, developing assays to examine the samples.

The new method identifies large immuno-active complexes in patients suffering from inflammation, exemplified here by rheumatoid arthritis. Unlike traditional methods, this approach allows for parallel measurement of patient samples, rather than serial testing, significantly increasing capacity. This technique offers a more precise evaluation of disease progression and facilitates more tailored treatment adjustments for individual patients. The next step for the researchers is to apply the same method to different patient cohorts. Expanding the testing to other autoimmune diseases seems to be a logical next step, with potential applications in autoimmune kidney diseases using urine samples, or autoimmune intestinal diseases using stool samples. These findings are not only promising for patients and healthcare providers, but they also hold significant interest for immunologists working to better understand immune system mechanisms.

"We have shown that large proteins are a marker for disease activity in both neurodegenerative and autoimmune diseases. The key point is that we have developed an entirely new kind of biomarker that isn’t measured today," said Assistant Professor Kristian Juul-Madsen from the Department of Biomedicine at Aarhus University, who is the last author of the study.


New
Gold Member
Cardiovascular Risk Test
Metabolic Syndrome Array I & II
Portable Electronic Pipette
Mini 96
New
Gold Member
Collection and Transport System
PurSafe Plus®
New
Gold Member
Hematology Analyzer
Medonic M32B
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Molecular Diagnostics

view channel
Image: Left is the original cell image and right is same cell image zoomed in and rendered in the special imaging software (Photo courtesy of FIU)

Brain Inflammation Biomarker Detects Alzheimer’s Years Before Symptoms Appear

Alzheimer’s disease affects millions globally, but patients are often diagnosed only after memory loss and other symptoms appear, when brain damage is already extensive. Detecting the disease much earlier... Read more

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Pathology

view channel
Image: An adult fibrosarcoma case report has shown the importance of early diagnosis and targeted therapy (Photo courtesy of Sultana and Sailaja/Oncoscience)

Accurate Pathological Analysis Improves Treatment Outcomes for Adult Fibrosarcoma

Adult fibrosarcoma is a rare and highly aggressive malignancy that develops in connective tissue and often affects the limbs, trunk, or head and neck region. Diagnosis is complex because tumors can mimic... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.