Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




AI-Powered Test Predicts Risk of Developing Esophageal Cancer in Patients with Barrett’s Esophagus

By LabMedica International staff writers
Posted on 16 May 2023

Barrett's esophagus (BE) is a serious consequence of gastroesophageal reflux disease (GERD) and presents a risk for the onset of esophageal cancer, one of the fastest-increasing cancers in terms of incidence in the U. More...

S., exhibiting a less than 20% five-year survival rate. Effective interventions such as ablation therapy are typically applied to patients with higher grades of BE to prevent its progression to esophageal cancer. However, a substantial number of BE patients are classified with lower grades of BE or as non-dysplastic. Despite population-based predictions indicating a low cancer development probability for these lower-grade patients, they constitute the majority of patients who ultimately progress to esophageal cancer. This discrepancy indicates a significant clinical need for personalized, biologically based risk-stratification information to ensure a better alignment between progression risk and the application of effective interventions.

Castle Biosciences’ (Pittsburgh, PA, USA) TissueCypher Barrett’s Esophagus test is the world’s first precision medicine test that predicts the future development of esophageal cancer in patients with BE. The TissueCypher test provides medical professionals with vital information regarding an individual patient's risk of progression to esophageal cancer based on advanced analysis of biopsy samples, thus enabling better-informed, risk-aligned patient management. Its clinical effectiveness has been validated through nine peer-reviewed publications involving BE progressor patients across leading clinical centers worldwide.

The TissueCypher test is designed for use in patients with endoscopic biopsy-confirmed BE that is graded as non-dysplastic, indefinite for dysplasia, or low-grade dysplasia. Precise and accurate prediction of progression from BE to high-grade dysplasia or esophageal adenocarcinoma is crucial, given the rapidly growing incidence of esophageal cancer. Since esophageal adenocarcinoma is highly fatal once diagnosed, early detection and advanced warning provided by the TissueCypher test in BE patients can offer crucial clinical decision support for physicians treating these patients. Castle Biosciences was selected as the winner of the “Best Use of Artificial Intelligence in Healthcare” award in the seventh annual MedTech Breakthrough Awards program for its innovative TissueCypher Barrett’s Esophagus test.

“Most cancer diagnoses and associated risk-stratification estimates are currently made by pathologists viewing tissue on glass slides via light microscopy. This approach is limited in its ability to evaluate multiple biomarkers and cell types within the tumor system and predict future development of cancer,” said James Johnson, managing director, MedTech Breakthrough. “TissueCypher utilizes artificial intelligence to predict the risk of developing esophageal cancer – one of the world’s most deadly cancers. Congratulations to the Castle team on winning the ‘Best Use of Artificial Intelligence in Healthcare’ award in 2023.”

Related Links:
Castle Biosciences 


Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
Portable Electronic Pipette
Mini 96
New
Laboratory Software
ArtelWare
New
Urine Chemistry Control
Dropper Urine Chemistry Control
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The VENTANA HER2 (4B5) test is now CE-IVDR approved (Photo courtesy of Roche)

Companion Diagnostic Test Identifies HER2-Ultralow Breast Cancer and Biliary Tract Cancer Patients

Breast cancer is the most common cancer in Europe, with more than 564,000 new cases and 145,000 deaths annually. Metastatic breast cancer is rising in younger populations and remains the leading cause... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.