We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Liquid Biopsy Predicts Prognosis of Gastric Cancer Following Chemotherapy or Surgery

By LabMedica International staff writers
Posted on 10 Feb 2020
Print article
Image: Photomicrograph showing poor to moderately differentiated adenocarcinoma of the stomach (Photo courtesy of Wikimedia Commons)
Image: Photomicrograph showing poor to moderately differentiated adenocarcinoma of the stomach (Photo courtesy of Wikimedia Commons)
A liquid biopsy approach, which utilized analyses of matched circulating DNA (cfDNA) and white blood cells from the same patient, was used to predict recurrence of gastric cancer in patients after surgery.

The prognosis of stomach cancer is generally poor, due to the fact the tumor has often metastasized by the time of discovery and the fact that most people with the condition are elderly (median age is between 70 and 75 years) at presentation.The average life expectancy after being diagnosed is around 24 months, and the five-year survival rate for stomach cancer is less than 10%. Almost 300 genes are related to outcomes in stomach cancer with both unfavorable genes where high expression related to poor survival and favorable genes where high expression associated with longer survival times.

Investigators at Johns Hopkins University (Baltimore, MD, USA) analyzed blood samples from 50 patients with gastric cancer who participated in the CRITICS trial, a phase III, randomized controlled study of chemotherapy given at about the time of surgery. The investigators performed deep sequencing of both circulating cell-free, tumor-derived DNA (ctDNA) and of white blood cells from the same patient. After filtering out changes found in the matched white blood cells, the presence of ctDNA predicted cancer recurrence when analyzed within nine weeks after preoperative treatment or shortly after surgery.

These analyses provided a easy method for distinguishing ctDNA from other cfDNA alterations and highlighted the utility of ctDNA as a predictive biomarker of patient outcome in patients with gastric cancer.

“We performed this study to see if we could predict whether gastric cancers would recur using noninvasive liquid biopsies. Using a deep sequencing approach of cell-free DNA and white blood cells, we found an outstanding prediction of whether the therapy was successful,” said senior author Dr. Victor Velculescu, professor of oncology, pathology, and medicine at Johns Hopkins University.

The liquid biopsy method was described in the January 27, 2020, online edition of the journal Nature Communications.

Related Links:
Johns Hopkins University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
POCT Fluorescent Immunoassay Analyzer
FIA Go
Gold Member
Xylazine Immunoassay Test
Xylazine ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.