We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Stunted Microbiota and Opportunistic Pathogen Colonize C-Section Birth

By LabMedica International staff writers
Posted on 10 Oct 2019
Immediately after birth, newborn babies experience rapid colonization by microorganisms from their mothers and the surrounding environment. More...
Infants born by caesarean section have gut microbiomes that differ from those of infants born vaginally, carrying more hospital-associated opportunistic pathogens.

Diseases in childhood and later in life are potentially mediated by the perturbation of the colonization of the infant gut microbiota. However, the effects of delivery via caesarean section on the earliest stages of the acquisition and development of the gut microbiota, during the neonatal period (≤1 month), remain controversial.

Scientists from the Wellcome Sanger Institute (Hinxton, UK) and their colleagues collected fecal samples from 596 healthy babies through the Baby Biome Study. All infants were sampled at least once during their first month of life and 302 were sampled again when they were a few months old. Of these babies, 314 were born vaginally and 282 by C-section. DNA was extracted from 30 mg of fecal samples and DNA samples, including negative controls, were quantified by PicoGreen dsDNA assay.

The team found that babies born vaginally had gut microbiomes enriched with commensal bacteria like Bifidobacterium, Escherichia, Bacteroides, and Parabacteroides. Babies born by caesarean section had gut microbiomes that were depleted of those commensal bacteria, but instead harbored hospital-associated bacteria like Enterococcus faecalis, Staphylococcus epidermis, Klebsiella pneumoniae, and Clostridium perfringens. They also profiled the gut microbiomes of 178 mother-baby pairs to find that Bacteroides, Parabacteroides, Bifidobacterium, and E. coli were most frequently transmitted from mother to baby during vaginal birth. They also noted that these bacteria did not originate from the mother's vaginal microbiome, but from her gut microbiome.

Nigel Field, PhD, an infectious disease epidemiologist and academic public health consultant and a senior author of the study, said, “After they have been weaned, the microbiome differences between babies born via caesarean and delivered vaginally have mainly evened out. We don't yet know whether the initial differences we found will have any health implications. The study was published on September 18, 2019, in the journal Nature.

Related Links:
Wellcome Sanger Institute


Gold Member
Veterinary Hematology Analyzer
Exigo H400
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
DNA/RNA Extraction/Purification Kit
Nucleic Acid Extraction or Purification Kit
New
Staining Management Software
DakoLink
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
Image: Pancreatic cancer diagnosis (Photo courtesy of World Journal of Gastroenterology)

AI-Driven Preliminary Testing for Pancreatic Cancer Enhances Prognosis

Pancreatic cancer poses a major global health threat due to its high mortality rate, with 467,409 deaths and 510,992 new cases reported worldwide in 2022. Often referred to as the "king" of all cancers,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.