We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

COPAN DIAGNOSTICS

COPAN (which stands for COllection and Preservation for ANalysis) is a global market leader in sample collection and ... read more Featured Products: More products

Download Mobile App




Flocked Swab Reveals Severe Diarrheagenic Babies Had Undiagnosed Infection

By LabMedica International staff writers
Posted on 09 Jun 2015
Print article
The FLOQSwab comprises of a solid molded plastic applicator shaft with a tip that can vary in size and shape
The FLOQSwab comprises of a solid molded plastic applicator shaft with a tip that can vary in size and shape (Photo courtesy of COPAN DIAGNOSTICS)
Diarrheal disease is a leading cause of death for young children and most pediatric gastroenteritis is caused by viral pathogens; consequently, current recommendations advocate against routine antibacterial therapy if children present without bloody stools.

An innovative 'flocked swab' improves diagnosis, treatment of deadly childhood diarrheal diseases and helped diagnosed previously unrecognized pathogens that had caused the severe diarrhea of over one-third of children in a group of southern Africa hospitals.

A team of scientists led by those at British Columbia Children's Hospital (Vancouver, BC, Canada) enrolled children with severe acute gastroenteritis admitted to a hospital in Botswana. Details of presenting history, physical examination, and course in the hospital were recorded. Stool samples were characterized using a 15 pathogen polymerase chain reaction assay. There were 671 participants with a median age of 8.3 months; 77 (11%) had severe acute malnutrition. Only 74 children had bloody stools, of whom 48 (65%) had a detectable bacterial pathogen, compared to 195 of 592 (33%) of those without. There were 26 deaths (3.9%).

Reverse transcription, amplification, and detection of 15 pathogen targets (three viruses, three parasites, and nine bacteria) were performed using the Gastrointestinal Pathogen Panel (GPP) assay on the MAGPIX system (Luminex Molecular Diagnostics; Toronto, Canada). The flocked rectal swab (FLOQSwab, Copan; Brescia, Italy) was used to eliminate the wait and biohazard involved in obtaining and transporting a bulk feces sample from an infant or child. This efficiency enabled implementation of a randomized clinical trial evaluating same-day diagnosis and treatment for a broad number of pathogens.

Children randomly chosen for rapid testing using the flocked swab and appropriate treatment were 55% less likely to have diarrhea recur, compared with children not chosen, and they had a clinically significant height gain after 60 days. This measure of growth is an important indicator of children's ability to reach their full developmental potential. Rotavirus was more commonly detected in younger children (42% of infants, 32% of children aged 12 to 24 months, and 12% of children aged more than 24 months), as was Campylobacter (15% of infants, 16% of children aged 12 to 24 months, and 2.0% of children aged more than 24 months). In contrast, Shigella was more often found in older children (9.6% of infants, 24% of children aged 12 to 24 months, and 47% of children aged more than 24 months as was Salmonella.

Peter Alexander Singer, OC, MD, MPH, FRSC, a professor and CEO of Grand Challenges Canada (Toronto, ON, Canada) said, “The simple fact is: Diagnostics save lives. If health workers can quickly and accurately pinpoint the cause of a child's illness, timely help can be administered, preventing many deaths and improving many lives. The flocked swab offers a shining example of the sort of 'Bold Idea with Big Impact' in global health.” The study was published on May 16, 2015, in the Journal of the Pediatric Infectious Disease Society.

Related Links:

British Columbia Children's Hospital  
Luminex Molecular Diagnostics 
Copan 


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Plasma Control
Plasma Control Level 1
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get complete access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Molecular Diagnostics

view channel
Image: Liquid biopsy could detect and monitor aggressive small cell lung cancer (Photo courtesy of Shutterstock)

Blood-Based Test Detects and Monitors Aggressive Small Cell Lung Cancer

Small cell lung cancer (SCLC) is a highly aggressive type of cancer known for its ability to metastasize. The behavior of tumors is largely governed by which genes are turned on, or transcribed, irrespective... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: The groundbreaking treatment approach has shown promise in hard-to-treat cancers (Photo courtesy of 123RF)

Genetic Testing Combined With Personalized Drug Screening On Tumor Samples to Revolutionize Cancer Treatment

Cancer treatment typically adheres to a standard of care—established, statistically validated regimens that are effective for the majority of patients. However, the disease’s inherent variability means... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.