We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
ZeptoMetrix an Antylia scientific company

Download Mobile App

Unique Metabolic Signature Could Enable Sepsis Diagnosis within One Hour of Blood Collection

By LabMedica International staff writers
Posted on 15 Apr 2024
Print article
Image: Dr. Sam Lodge found that metabolic signatures can shift the speed of sepsis diagnosis (Photo courtesy of Murdoch University)
Image: Dr. Sam Lodge found that metabolic signatures can shift the speed of sepsis diagnosis (Photo courtesy of Murdoch University)

Sepsis is a life-threatening condition triggered by an extreme response of the body to an infection. It requires immediate medical intervention to prevent potential death or lasting damage. Delay in diagnosing patients with sepsis or septic shock is linked with heightened mortality and morbidity, emphasizing the critical need for prompt diagnosis to improve survival rates. Now, new research findings promise faster diagnosis and better outcomes for sepsis and septic shock patients.

In the study led by Murdoch University (Perth, Australia), researchers successfully used blood plasma metabolic phenotyping to accurately diagnose sepsis or septic shock within an hour of collecting blood samples. This method marks a significant improvement over traditional pathogen culturing techniques, which may take days to yield results. According to the researchers, metabolic signatures were the key to the breakthrough. The study involved the analysis of blood plasma samples collected from 152 patients admitted to the Intensive Care Unit (ICU) within 48 hours—comprising 62 without sepsis, 71 with sepsis, and 19 with septic shock.

The metabolic profiling revealed that patients with sepsis or septic shock displayed higher levels of neopterin and lower levels of HDL cholesterol and phospholipid particles compared to those without sepsis. Septic shock patients could be differentiated from those with only sepsis through different concentrations of 10 specific lipids, including notably reduced levels of five phosphatidylcholine species, three cholesterol esters, one dihydroceramide, and one phosphatidylethanolamine. Utilizing these 15 parameters, which include various metabolites, lipids, lipoproteins, and inflammatory markers, the study achieved high accuracy in accurately classifying patients into their respective clinical outcomes. The research underscores the potential of plasma metabolic phenotyping within 48 hours of ICU admission as a dependable tool for diagnosing sepsis and differentiating between sepsis and septic shock based on lipid profiles.

“As well as impacting individuals and families, sepsis and septic shock pose a significant economic burden to our society,” said Dr. Sam Lodge, from Murdoch University’s Australian National Phenome Centre. “While further validation with a larger cohort is required, this study provides a proof of concept for the potential use of metabolic phenotypes in better diagnosing these conditions.”

Related Links:
Murdoch University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Automatic Nucleic Acid Extractor
GeneRotex 24

Print article


Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more


view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more


view channel
Image: The novel test uses an existing diagnostic procedure as its basis to target the Epstein Barr Virus (Photo courtesy of 123RF)

Blood Test Measures Immune Response to Epstein-Barr Virus in MS Patients

Multiple sclerosis (MS) is a chronic neurological condition for which there is currently no cure. It affects around three million people globally and ranks as the second most common cause of disability... Read more


view channel
Image: Insulin proteins clumping together (Photo courtesy of Jacob Kæstel-Hansen)

AI Tool Detects Tiny Protein Clumps in Microscopy Images in Real-Time

Over 55 million individuals worldwide suffer from dementia-related diseases like Alzheimer's and Parkinson's. These conditions are caused by the clumping together of the smallest building blocks in the... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.