We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
23 Sep 2021 - 25 Sep 2021

Immunoglobulin Levels Investigated in Adults with IgG Subclass Deficiency

By LabMedica International staff writers
Posted on 30 Aug 2021
Print article
Image: Blood sample tube for Immunoglobulin G or IgG subclass test (Photo courtesy of Blood Tests London)
Image: Blood sample tube for Immunoglobulin G or IgG subclass test (Photo courtesy of Blood Tests London)
Immunoglobulin G (IgG) subclass deficiency (IgGSD) is characterized by frequent or severe upper or lower respiratory tract infection, one or more subnormal IgG subclass level(s) unexplained by other causes, and decreased IgG response to pneumococcal polysaccharide vaccination (PPSV).

IgG subclass deficiency is defined as the decrease of one or more subclasses of IgG antibodies with normal or near normal levels of other immunoglobulin classes. It can present as either as a complete deficiency in instances in which the serum level of a IgG subclass are below detection or as a relative deficiency in which the IgG subclass levels are below normal range for age.

Medical Scientists at the University of Alabama at Birmingham (Birmingham, AL, USA) analyzed data on 207 adults: 39 with subnormal IgG1 only; 53 with combined subnormal IgG1/IgG3; and 115 with subnormal IgG3 only. They compiled data on age; sex; autoimmune condition(s) (AC); atopy; IgG, IgG subclasses, IgA, IgM; IgGsum (IgG1 + IgG2 + IgG3 + IgG4); and D (Δ percentage difference between IgGsum and IgG).

The team compared attributes of patients with/without subnormal IgG (< 7.00 g/L; subnormal IgG1 subclass groups only) and analyzed IgGsum and IgG relationships. IgG at diagnosis in each patient was measured using turbidimetry (Laboratory Corporation of America, Burlington, NC, USA). IgG subclasses were measured using four separate quantifications on corresponding specimens using rate nephelometry (Laboratory Corporation of America), and reported separately from IgG. IgG and IgG subclasses were measured before IgG replacement therapy was initiated.

The investigators reported that there were 39 patients with subnormal IgG1 only (89.7% women), 53 with subnormal IgG1/IgG3 (88.7% women), and 115 with subnormal IgG3 only (91.3% women). Fifteen patients (38.5%) and 32 patients (60.4%) in the respective subnormal IgG1 subclass groups had subnormal IgG. Attributes of patients with/without IgG < 7.00 g/L were similar, except that autoimmune condition prevalence was lower in patients with subnormal IgG1 only and IgG < 7.00 g/L than ≥ 7.00 g/L. Mean/median IgG1 and IgG2 were significantly lower in patients with IgG < 7.00 g/L in both subnormal IgG1 subclass groups. Regression analysis on IgG in three subclass groups revealed positive associations with IgG1 and IgG2.

The authors concluded that both IgG1 and IgG2 are major determinants of IgG in patients with subnormal IgG1, combined subnormal IgG1/IgG3, or subnormal IgG3 and that in patients with subnormal IgG1 or combined subnormal IgG1/IgG3, median IgG2 levels are significantly lower in those with IgG < 7.00 g/L than those with IgG ≥ 7.00 g/L. The study was published on August 9, 2021 in the journal BMC Immunology.

Related Links:
University of Alabama at Birmingham
Laboratory Corporation of America


Gold Supplier
NEW PRODUCT : SILICONE WASHING MACHINE TRAY COVER WITH VICOLAB SILICONE NET VICOLAB®
REGISTRED 682.9
New
Silver Supplier
COVID-19 NAb Test Solution
COVID-19 NAb Test Solution
New
Silver Supplier
Automated Body Fluid Cell Count Control
Cell-Chex Auto
New
Laboratory Management Software
HERA

Print article

Channels

Pathology

view channel
Image: The CellSearch Circulating Tumor Cell Kit is intended for the enumeration of circulating tumor cells of epithelial origin (CD45-, EpCAM+, and cytokeratins 8, 18+, and/or 19+ and PD-L1) in whole blood (Photo courtesy of CellSearch/Menarini Silicon Biosystems)

PD-L1 Expression in Circulating Tumor Cells Investigated for NSCLC

In non-small cell lung cancer (NSCLC), analysis of programmed cell death ligand 1 (PD-L1) expression in circulating tumor cells (CTCs) is a potential alternative to overcome the problems linked to the... Read more

Industry

view channel
Illustration

Global Digital Polymerase Chain Reaction (dPCR) Market Projected to Reach Close to USD 1.15 Billion by 2028

The global digital polymerase chain reaction (dPCR) market is projected to grow at a CAGR of more than 9% from over USD 0.50 billion in 2020 to nearly USD 1.15 billion by 2028, driven primarily by rising... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.