We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
20 Oct 2021 - 22 Oct 2021
21 Oct 2021 - 24 Oct 2021
Virtual Venue

Two Inflammatory Proteins Linked with Slower Cognitive Decline

By LabMedica International staff writers
Posted on 08 Jul 2021
Print article
Image: Elevated levels of two inflammatory proteins, IL-12p70 and IFN-γ, were associated with slower cognitive decline in older adults (Photo courtesy of Scientific Animations Inc)
Image: Elevated levels of two inflammatory proteins, IL-12p70 and IFN-γ, were associated with slower cognitive decline in older adults (Photo courtesy of Scientific Animations Inc)
Previous meta-analyses of case-control and prospective cohort studies showed that cytokines and inflammatory markers, such as interleukin-6 (IL-6), C-reactive protein (CRP), and others are elevated in Alzheimer's dementia cases and predicted incident of all-cause dementia.

While it seems counterintuitive that people with high levels of inflammation-inducing proteins are protected against cognitive decline, it may be that their immune systems are better primed to fight infection. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta (Aβ), remains unclear.

A team of Medical Scientists at the Harvard Medical School (Boston, MA, USA) and their colleagues measured nine cytokines in the baseline plasma of 298 longitudinally followed CU elderly and assessed whether these measures were associated with cognitive decline, alone or synergistically with Aβ. They next examined associations between cytokine levels and neuroimaging biomarkers of Aβ/tau/neurodegeneration. The mean baseline age was 72; 62% were female and 81% were white and participants were followed an average of 4.3 years.

The investigators reported that neither IL-12p70 nor IFN-γ was associated with age, sex, or APOE4 carrier status. Immunosuppressant medication use did not affect baseline IL-12p70 or IFN-γ levels. Concentrations of IL-12p70 and IFN-γ from the same individual remained stable on repeat measures up to several years apart. Higher IL-12p70 was associated with slower cognitive decline in the setting of higher amyloid-beta. Higher IFN-γ was associated with slower cognitive decline independent of amyloid burden. Higher IL-12p70 was associated with less neocortical tau on PET and hippocampal neurodegeneration in people with a higher amyloid-beta burden. IFN-γ was not correlated with tau or neurodegeneration.

Rudolph E. Tanzi, PhD, a Professor of Neurology and senior author of the study, said, “Greater IL-12/IFN-γ axis activation may be protective against cognitive decline and early-stage Alzheimer's disease progression. Moreover, the effect sizes of IL-12 and IFN-γ in predicting cognitive decline were statistically significant, but small. "These cytokines should be considered ancillary biomarkers rather than stand-alone prognostic indicators.” The study was published on June 23, 2021 in the journal Alzheimer's & Dementia.

Related Links:
Harvard Medical School

New
Gold Supplier
Centrifuge
Multifuge X4 Pro Centrifuge Series
New
Real Time PCR Platform
VIASURE V-Lab96
New
Automated Immunoassay System
GSD Thunderbolt
New
Silver Supplier
Automated RPR Syphilis Test
Automated RPR Test Kit

Print article

Channels

Molecular Diagnostics

view channel
Image: The QuikRead go iFOBT is an immunochemical fecal immunochemical test for detection and quantification of human hemoglobin in feces in case of suspected bleeding from the lower gastrointestinal tract (Photo courtesy of Aidian)

Fecal Immunochemical Tubes Sourced to Analyze Gut Microbiome for CRC

Colorectal cancer (CRC) is a challenging public health problem which successful treatment depends on the stage at diagnosis. Recently, CRC-specific microbiome signatures have been proposed as a marker... Read more

Hematology

view channel
Image: Bone marrow aspirate from a patient with peripheral T-cell lymphoma (Photo courtesy of Peter Maslak, MD)

Mutation Analysis Links Angioimmunoblastic T-Cell Lymphoma to Clonal Hematopoiesis

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of lymphoid tumors and encompass peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), angioimmunoblastic T-cell lymphoma (AITL), and... Read more

Industry

view channel
Image: GastroPanel Quick Test (Photo courtesy of Biohit Healthcare)

Biohit’s Innovative GastroPanel Quick Test Receives CE Mark

Biohit Healthcare’s (Helsinki, Finland) GastroPanel Quick Test, the latest innovation in its unique GastroPanel product family, is now CE marked. The GastroPanel Quick Test is intended for diagnosing... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.