We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
04 May 2021 - 07 May 2021
Virtual Venue

Handheld Mass Spectrometer Identifies Cancer Tissue in Seconds

By LabMedica International staff writers
Posted on 19 Sep 2017
Print article
Image: The MasSpec Pen rapidly and accurately detects live cancer during surgery, helping improve treatment and reduce the chances of cancer recurrence (Photo courtesy of the University of Texas at Austin).
Image: The MasSpec Pen rapidly and accurately detects live cancer during surgery, helping improve treatment and reduce the chances of cancer recurrence (Photo courtesy of the University of Texas at Austin).
A team of scientists and engineers has invented a powerful device that rapidly identifies living cancerous tissue, giving surgeons precise diagnostic information about what tissue to cut or preserve.

“If you talk to cancer patients after surgery, one of the first things many will say is ‘I hope the surgeon got all the cancer out’,” said Livia Schiavinato Eberlin, assistant professor at University of Texas at Austin (Austin, TX, USA) who designed the study and led the team, “our technology could vastly improve the odds that surgeons really do remove every last trace of cancer during surgery.”

The current method, Frozen Section Analysis, for diagnosis and determining the boundary between cancer and normal tissue during surgery is slow and sometimes inaccurate. Each sample can take 30 minutes or more to prepare and interpret by a pathologist, increasing risk to the patient of infection and negative effects of anesthesia. For some types of cancers frozen section interpretation can be difficult, often yielding unreliable results.

The new MasSpec Pen took about 10 seconds to provide a diagnosis and was over 96% accurate in tests on tissues removed from 253 human cancer patients. It also detected cancer in marginal regions between normal and cancer tissues that presented mixed cellular composition.

This technology also offers the patient a safer surgery. “It allows us to be much more precise in what tissue we remove and what we leave behind,” said project collaborator James Suliburk, of Baylor College of Medicine. Although maximizing cancer removal is critical, removing too much healthy tissue can also have profound negative consequences: For example, breast cancer patients could experience higher risk of painful side effects and nerve damage, in addition to aesthetic impacts. Thyroid cancer patients could lose speech ability or the ability to regulate the body’s calcium levels in ways important for muscle and nerve function.

Living cells produce metabolites and each type of cancer produces a unique set of metabolites and other biomarkers. “Because the metabolites in cancer and normal cells are so different, we extract and analyze them with the MasSpec Pen to obtain a molecular fingerprint of the tissue. What is incredible is that through this simple and gentle chemical process, the MasSpec Pen rapidly provides diagnostic molecular information without causing tissue damage,” said Prof. Eberlin.

The molecular fingerprint obtained by the MasSpec Pen from an uncharacterized tissue sample is instantaneously evaluated by a “statistical classifier” software trained on a database of molecular fingerprints that Prof. Eberlin and her colleagues gathered from the 253 human tissue samples. The samples included both normal and cancerous tissues of the breast, lung, thyroid, and ovary.

The pen releases a drop of water onto the tissue, and small molecules migrate into the water. The water sample is driven into a mass spectrometer, which detects thousands of molecules as a molecular fingerprint. The disposable device requires simply holding the pen against the patient’s tissue, triggering the automated analysis using a foot pedal, and waiting a few seconds for a result.

In tests performed on human samples, the device was more than 96% accurate for cancer diagnosis. It also diagnosed cancer in live, tumor-bearing mice during surgery without causing observable tissue harm or stress to the animals.

So the process would be low-impact for patients and biocompatible. “When designing the MasSpec Pen, we made sure the tissue remains intact by coming into contact only with water and the plastic tip of the MasSpec Pen during the procedure,” said Prof. Zhang.

The study, by Zhang J et al, was published September 6, 2017, in the journal Science Translational Medicine.

Related Links:
University of Texas at Austin

New
Gold Supplier
COVID-19 Coronavirus and Influenza A/B Virus Real Time PCR Kit
COVID-19 Coronavirus and Influenza A/B Virus Real Time PCR Kit
Silver Supplier
SARS-CoV-2 RT-PCR Assay
ErbaMDx SARS-COV-2 RT-PCR Kit
New
SARS-CoV-2 Recombinant Antigens
SARS-CoV-2 Recombinant Antigens
New
Gold Supplier
SARS-CoV-2 Rapid Test
Vivalytic SARS-CoV-2 Rapid 39 Minute Test

Print article
BIOHIT  Healthcare OY

Channels

Molecular Diagnostics

view channel
Image: Randox Discovery Diagnostic Analyzer Wins 2021 Red Dot Award for High Design Quality (Photo courtesy of Randox Laboratories)

Randox Discovery Diagnostic Analyzer Wins 2021 Red Dot Award for High Design Quality

Randox Laboratories’ (Crumlin, UK) Discovery, a diagnostic analyzer which can consolidate molecular and immunoassay testing on one compact benchtop platform, has received the 2021 Red Dot Award for High... Read more

Industry

view channel
Image: Eppendorf Centrifuge 5910 Ri (Photo courtesy of Eppendorf AG)

Eppendorf Introduces Multipurpose Centrifuge 5910 Ri to Accelerate Results

Eppendorf AG (Hamburg, Germany) has introduced a new centrifuge designed to increase efficiency in the laboratory, Centrifuge 5910 Ri, a successor to the company’s popular Centrifuge 5910 R.... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.