We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Sekisui Diagnostics UK Ltd.

Download Mobile App




Gold Nanoparticle-Based Test Better for Prostate Cancer Diagnosis Than PSA

By LabMedica International staff writers
Posted on 13 Apr 2015
Print article
Image: Illustration of the NanoDLSay light scattering assay for detecting target analytes by measuring nanoparticle size change (Photo courtesy of Nano Discovery Inc.).
Image: Illustration of the NanoDLSay light scattering assay for detecting target analytes by measuring nanoparticle size change (Photo courtesy of Nano Discovery Inc.).
A rapid and simple gold nanoparticle-based blood test proved better at diagnosing prostate cancer than did the commonly used PSA (prostate-specific antigen) assay.

Investigators at the University of Central Florida (Orlando, USA) based their NanoDLSay test on the ability of gold nanoparticles to bind certain proteins from the serum and to increase in size and change their light scattering properties.

When citrate ligands-capped gold nanoparticles are mixed with blood sera, a protein corona is formed on the nanoparticle surface due to the adsorption of various proteins in the blood to the nanoparticles. Using a two-step gold nanoparticle-enabled dynamic light scattering assay, the investigators discovered that the amount of human immunoglobulin G (IgG) in the gold nanoparticle protein corona was increased in prostate cancer patients compared to healthy controls. Two pilot studies conducted on blood serum samples collected at Florida Hospital (USA) and obtained from the Prostate Cancer Biorespository Network revealed that the test had 90%–95% specificity and 50% sensitivity in detecting early stage prostate cancer, representing a significant improvement over the current PSA test.

The investigators postulated that the increased amount of human IgG found in the protein corona was associated with the autoantibodies produced in cancer patients as part of the immune system's defense against the tumor. Proteomic analysis of the nanoparticle protein corona revealed molecular profile differences between serum samples from cancer patients and healthy individuals. Autoantibodies and natural antibodies produced in cancer patients in response to tumorigenesis have been found and detected in the blood of many cancer types. Thus, the test may be applicable for early detection and risk assessment of a broad spectrum of cancer types.

"What is different and unique about our technique is it is a very simple process, and the material required for the test is less than one USD," said senior author Dr. Qun Huo, professor of chemistry at the University of Central Florida. "And because it is low-cost, we are hoping most people can have this test in their doctor's office. If we can catch this cancer in its early stages, the impact is going to be big."

The investigators have founded the biomedical company Nano Discovery Inc. (Orlando, FL, USA) to commercialize the NanoDLSay diagnostic test for prostate cancer.

The report was published in the March 10, 2015, online edition of the journal ACS Applied Materials & Interfaces.

Related Links:
University of Central Florida
Nano Discovery Inc.


New
Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Print article

Channels

Molecular Diagnostics

view channel
Image: The HelioLiver Dx test has met the coprimary and secondary study endpoints in the CLiMB trial (Photo courtesy of Helio Genomics)

Blood-Based Test Outperforms Ultrasound in Early Liver Cancer Detection

Patients with liver cirrhosis and chronic hepatitis B are at a higher risk for developing hepatocellular carcinoma (HCC), the most prevalent type of liver cancer. The American Association for the Study... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Microbiology

view channel
Image: The POC PCR test shortens time for STI test results (Photo courtesy of Visby Medical)

POC STI Test Shortens Time from ED Arrival to Test Results

In a 2024 sexually transmitted infections (STIs) surveillance report by the World Health Organization (WHO), over 2.5 million cases were recorded, alongside a rise in the inappropriate use of antibiotics... Read more

Industry

view channel
Image: For 46 years, Roche and Hitachi have collaborated to deliver innovative diagnostic solutions (Photo courtesy of Roche)

Roche and Hitachi High-Tech Extend 46-Year Partnership for Breakthroughs in Diagnostic Testing

Roche (Basel, Switzerland) and Hitachi High-Tech (Tokyo, Japan) have renewed their collaboration agreement, committing to a further 10 years of partnership. This extension brings together their long-standing... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.