We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Regenerative Potential Is a Trait of Mature Tissues, Not an Innate Feature of Newly Born Cells

By LabMedica International staff writers
Posted on 25 Mar 2015
Diabetes researchers have found that the ability of insulin-producing beta cells to replicate and respond to elevated glucose concentrations is absent in very young animals and does not appear until after weaning.

Since the ability to regenerate tissue deteriorates with age, it was generally assumed that the younger the animal, the better it could compensate for damage tissues or organs. More...


Investigators at the Hebrew University of Jerusalem (Israel) examined the effect of young age on compensatory proliferation of pancreatic beta cells in vivo. Much to their surprise, they found that beta cells in suckling mice failed to enter the cell division cycle in response to a diabetes induced injury or increased glycolysis. However, when the mice were weaned to a high carbohydrate diet of pet chow—but not to a high fat diet that mimicked their mothers' milk—they developed the capacity for compensatory proliferation.

Weaning coincided with enhanced glucose-stimulated oxidative phosphorylation and insulin secretion from islets. Transcriptome analysis revealed that weaning increased the expression of genes involved in replication licensing, suggesting a mechanism for increased responsiveness to the mitogenic activity of high glucose. The investigators proposed in a paper published in the March 9, 2015, issue of the journal Developmental Cell that weaning triggered a discrete maturation step of beta cells that elevated both their mitogenic and secretory response to glucose. In light of these findings, the investigators will be searching for the exact molecular signal or pathway that triggered these events.

Senior author Dr. Yuval Dor, professor of developmental biology and cancer research at the Hebrew University of Jerusalem, said, “The data suggest that regenerative potential is a trait of mature tissues, which has to develop actively, similar to functional maturation, rather than an innate feature of newly born cells.”

Related Links:

Hebrew University of Jerusalem



New
Gold Member
Serological Pipets
INTEGRA Serological Pipets
Serological Pipet Controller
PIPETBOY GENIUS
New
Gram-Negative Blood Culture Assay
LIAISON PLEX Gram-Negative Blood Culture Assay
New
Capillary Blood Collection Tube
IMPROMINI M3
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: EvoLiver is the first test to receive FDA Breakthrough Device Designation in five years in the liver cancer surveillance space (Photo courtesy of Mursla Bio)

Patient-Friendly Blood Test to Transform Liver Cancer Surveillance

Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is the fastest-growing cause of cancer-related deaths. Although clinical guidelines recommend routine surveillance for high-risk... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: CellLENS enables the potential precision therapy strategies against specific immune cell populations in the tissue environment (Photo courtesy of MIT)

New AI System Uncovers Hidden Cell Subtypes to Advance Cancer Immunotherapy

To produce effective targeted therapies for cancer, scientists need to isolate the genetic and phenotypic characteristics of cancer cells, both within and across different tumors. These differences significantly... Read more

Technology

view channel
Image: The Check4 gene-detection platform (Photo courtesy of IdentifySensors)

Electronic Biosensors Used to Detect Pathogens Can Rapidly Detect Cancer Cells

A major challenge in healthcare is the early and affordable detection of serious diseases such as cancer. Early diagnosis remains difficult due to the complexity of identifying specific genetic markers... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.