New Approach Restores Effectiveness of Older Antibiotics

The β-lactam structure in a molecule is something that many bacteria are adverse to. It greatly hinders their ability to reproduce by cell division, and so chemists have for years spent time making molecules that all contain the β-lactam structural motif. One of the most effective bacterial defenses is an enzyme called β-lactamase, which chews up the β-lactam structure. Some bacteria, such as MRSA, have developed the ability to biosynthesize and release β-lactamase when needed. It is a devastating defense because it is so general, targeting the common structural motif in all of the many β-lactam antibiotics.

The interdisciplinary team also showed that the antimicrobial effectiveness of the four β-lactams studied in detail was enhanced by the polymer. They prepared a cobaltocenium metallopolymer that greatly slowed the destructiveness of β-lactamase on a model β-lactam molecule (nitrocefin). The enhancement was modest against two strains, but very pronounced with the hospital-associated strain of MRSA (HA-MRSA). The four antibiotics penicillin-G, amoxicillin, ampicillin, and cefazolin, were protected from β-lactamase hydrolysis via the formation of unique ion-pairs between their carboxylate anions and cationic cobaltocenium moieties.

The study was published on March 17, 2014, in the Journal of the American Chemical Society.

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