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Molecular Diagnostics

Image: A histopathology showing simple columnar metaplasia of the epithelium of Barrett\'s Esophagus characterized by goblet cell (Photo courtesy of Nephron).

Genetic Analysis of Lesions Provides Accurate Esophageal Cancer Test

Barrett's Esophagus is a common condition that affects an estimated 1.5 million people in the UK alone, although many are undiagnosed. This condition involves normal cells in the esophagus being replaced by an unusual cell type called Barrett's Esophagus, and is thought to be a consequence of chronic reflux or heartburn. More...
31 Aug 2016
Image: The Mastercycler nexus thermal cycler (Photo courtesy of Eppendorf).

Molecular Testing Accuracy for Clostridium difficile Scrutinized

Accurate diagnosis of Clostridium difficile infection (CDI) is paramount for patient management and the wrong diagnosis places patients at risk, delays treatment, and/ or contributes to transmission of infection in the healthcare setting. More...
31 Aug 2016

Study Leads to Improved Diagnosis of Inherited Heart Muscle Disease

In a groundbreaking study of Mendelian gene pathogenicity, using comparative population genetics, researchers have developed more accurate diagnostics for inherited cardiomyopathy. The approach improves interpretation of the medical significance of gene mutations in patients being tested for a genetic condition. More...
29 Aug 2016
Image: The Rotor-Gene real-time PCR system (Photo courtesy of Qiagen).

Early Detection Identified for Leukemia Patients' Resistance to Therapy

A world-first breakthrough in the early detection of patients' resistance to a common treatment for chronic myeloid leukemia has been made. The discovery offers some hope that the patients' treatment could be changed sooner to improve their chances of survival. More...
25 Aug 2016
Image: The NucliSENS EasyMAG automated platform for total DNA extraction (Photo courtesy of BioMérieux).

Cell-Free DNA Sequencing Confirms Myelodysplastic Syndrome Diagnosis

The use of next-generation sequencing (NGS) methods to analyze cell-free DNA (cf-DNA) in the blood of patients with myelodysplastic syndrome (MDS) yields more accurate results than the current standard approach of Sanger sequencing. More...
25 Aug 2016
Image: A Denovix DS-11 spectrophotometer (Photo courtesy of Denovix).

Simple Sensitive Assays Used for Analyzing Fragile X Syndrome

Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the fragile X mental retardation 1gene (FMR1) that are difficult to analyze. More...
25 Aug 2016
Image: The QX100 Droplet digital PCR reader (Photo courtesy of Bio-Rad).

Droplet Digital PCR Rapidly Detects Alpha-Thalassemia Variants

Alpha (α)-thalassemia is a highly prevalent genetic disease worldwide and it is characterized by various degrees of alpha globin chain deficit caused by either deletional or non-deletional mutations although the former are more common. More...
24 Aug 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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