Regenerative Medicine Aided by Nanotechnology Strategies

Stem cells are an important potential source for repairing injured human tissues. Researchers have found that the adhesion, growth, and differentiation of stem cells are most probably controlled by their surrounding microenvironment, which contains both physical and chemical signals. These signals include the “nanotopography” of the complicated extracellular matrix that comprises a network for human tissues.

Dr. Yang-Kao Wang and colleagues from Taipei Medical University (Taipei City, Taiwan) described in their article studies showing how this nanotopography (which includes nanosized pores, ridges, and grooves) plays critical roles in the behavior and fate of stem cells. The authors also discussed the application of nanoparticles to stem cell isolation, tracking and imaging; how to convert nanotechnology tools from two to three dimensions; and the potential limitations of using nanomaterials in stem cell biology.

The authors concluded that “understanding [the] interactions of nanomaterials with stem cells may provide knowledge applicable to [the development of improved] cell-scaffold combinations in tissue engineering and regenerative medicine.”

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Taipei Medical University