We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Blood Test-Based Method Diagnoses Bile Acid Diarrhea from Single Sample

By LabMedica International staff writers
Posted on 07 Jul 2023
Print article
Image: A new method makes it easier to identify the right treatment for bile acid diarrhea (Photo courtesy of Freepik)
Image: A new method makes it easier to identify the right treatment for bile acid diarrhea (Photo courtesy of Freepik)

Bile acid malabsorption, also known as bile acid diarrhea, is a type of chronic diarrhea characterized by more than ten sudden episodes of diarrhea in a day. While the condition isn't life-threatening, it can severely disrupt a patient's day-to-day life, particularly their social activities, and can be significantly debilitating. Often, most instances of bile acid diarrhea are either diagnosed at an advanced stage or go undetected entirely, resulting in patients enduring this condition for several years before receiving a diagnosis. Now, a new study has discovered innovative methods for diagnosing bile acid diarrhea and identifying the most effective treatment tailored for each patient.

A team of researchers at University of Copenhagen (Copenhagen, Denmark) has devised a new approach for diagnosing bile acid diarrhea using a simple blood sample. This new technique focuses on blood molecules referred to as metabolites. A blood sample comprises several distinct metabolites. Among the nearly 1,300 identified metabolites, about a handful can be utilized to diagnose bile acid diarrhea. The metabolites in bile acid diarrhea patients form a specific pattern, making them easily identifiable.

For their research, the team examined blood samples from 50 patients and quickly observed that the samples – and by extension, the patients – could be segregated into two groups. Following this, the patients participated in a randomized clinical study where the researchers explored the effects of two different treatments: the standard treatment with bile acid sequestrant colesevelam and a novel treatment with liraglutide, typically used to manage type 2 diabetes and severe obesity. The clinical study revealed that while colesevelam treatment alleviated the bile acid diarrhea symptoms in 50% of the patients, liraglutide treatment proved successful for 77% of the patients.

“What is interesting is that the metabolites in the patients’ blood divided them into two groups: one that responds well to colesevelam and one that responds well to liraglutide. This suggests that we should be able to say which treatment is the most effective by analyzing the patient’s blood at the time of diagnosis,” said Professor Jesper Bøje Andersen from the Biotech Research & Innovation Centre.

Related Links:
University of Copenhagen 

Platinum Supplier
Automatic Nucleic Acid Workstation
Gold Supplier
hCG Whole Blood Pregnancy Test
Hepatitis B Virus Test
Yellow Fever Virus Test
Yellow Fever Virus IgG – ELISA

Print article


Molecular Diagnostics

view channel
Image: A CRISPR technology-based diagnostic test detects MPXV in clinical samples with acute precision (Photo courtesy of 123RF)

Powerful Diagnostic Tool Accurately Detects Monkeypox Virus Faster Than Any Method

At present, testing for the monkeypox virus (MPXV) is done mainly in centralized labs, and it can take days to get results due to location and logistical issues. Now, researchers have leveraged cutting-edge... Read more


view channel
Image: The US FDA has cleared HemoScreen point of care CBC for direct capillary sampling (Photo courtesy of PixCell Medical)

Point of Care CBC Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput

The world’s only 5-part differential Complete Blood Count (CBC) analyzer that is FDA-cleared, CE-marked, and TGA-approved for point-of-care use has now been granted FDA 510(k) clearance for direct capillary... Read more


view channel
Image: Immune cells present long before infection predict flu symptoms (Photo courtesy of Shutterstock.com)

Single Blood Draw to Detect Immune Cells Present Months before Flu Infection Can Predict Symptoms

For decades, if not centuries, scientists have struggled to solve the mystery of why certain individuals fall ill to infections while others remain unaffected. In an impressive development, researchers... Read more


view channel
Image: The rapid diagnostic test could pinpoint the correct antibiotic for infection treatment in under an hour (Photo courtesy of Microplate Dx)

Point-of-Care Device to Reduce Antibiotic Susceptibility Testing Time from Days to Minutes

Antimicrobial resistance (AMR) is a significant global health issue, currently leading to over 1.27 million deaths worldwide each year. By 2050, AMR could be causing up to 10 million deaths annually, surpassing... Read more


view channel
Image: The Tasso+ device has received CE Mark certification (Photo courtesy of Tasso)

Groundbreaking Blood Lancing Device Obtains Microliter Capillary Whole Blood Samples Painlessly

A convenient, virtually pain-free blood lancet that collects whole liquid blood samples has received CE Mark designation, making the patient-centric, high-volume blood collection solution available in... Read more


view channel
Image: A new electrochemical device can quickly and inexpensively identify people at greatest risk for osteoporosis (Photo courtesy of ACS Central Science, 2023)

Electrochemical Device Identifies People at Higher Risk for Osteoporosis Using Single Blood Drop

With the global increase in life expectancy, the incidence of age-related conditions like osteoporosis is increasing. Osteoporosis, affecting around 200 million individuals worldwide, has a higher incidence... Read more


view channel
Image: The global fully automatic electrolyte analyzers market is projected to reach close to USD 0.77 billion by 2032 (Photo courtesy of 123RF)

Global Fully Automatic Electrolyte Analyzers Market Driven by Surge in Demand for Point-of-Care Testing

Fully automatic electrolyte analyzers can measure the levels of electrolytes in various bodily fluids like blood and plasma. Electrolytes are ions that have an electrical charge and are essential for multiple... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.