Novel Apparatus Mimics the Human Digestive System for Oral Drug Studies

A team of British drug developers has created an instrument that mimics the human digestive system, which will allow them to accurately determine how orally-administered medications are dissolved and then absorbed.

Investigators at the University of Huddersfield (United Kingdom) sought a way to study the behavior of oral drugs in the digestive tract that would avoid the differences between the digestive systems of humans and laboratory animals.

To this end, they developed an apparatus for testing drug solubility that included a chamber for holding a solvent medium —often a bicarbonate based buffer system—as well as a pH probe connected to tanks of carbon dioxide and helium.

The heart of the apparatus was the control unit that monitored changes in pH of the solvent medium and, as appropriate, fed pH increasing and/or pH reducing gas from the tanks into the chamber. More...