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Image: Researchers have devised a new high-resolution method for studying which genes are active in a tissue. The method can be used on all types of tissue and is valuable to both preclinical research and cancer diagnostics (Photo courtesy of the Karolinska Institutet / the Royal Institute of Technology).

Spatial Transcriptomics Technique Enables Visualization of Gene Expression in Tissues

A team of Swedish researchers has developed a high-resolution method for resolving the transcriptome – the library of active genes and RNAs – in histological samples of patients' tissues. More...
12 Jul 2016
Image: The Rapid Rabies Ag Test Kit is a chromatographic immunoassay for the qualitative detection of Rabies virus antigen (Photo courtesy of Creative Diagnostics).

Evaluation of Rapid Rabies Tests Reveals Problems with Accuracy

If humans bitten by a rabid animal are treated quickly, the disease can usually be prevented but such post-exposure prophylaxis is expensive and should be reserved for bites from animals with confirmed infection, but testing dogs for rabies in resource-poor settings is challenging. More...
06 Jul 2016
Image: Base stacking adhesive forces versus OPTIMuS actuators. (a) The interface makeup between the ring and frameR shown as a cross-section of OPTIMuS. It can be modified with coaxial blunt ends (BE) to create high adhesion or no blunt ends to minimize adhesion. (b) FRET output of all blunt ends (All BE) versus no blunt ends (No BE) OPTIMuS upon the addition of different force domains (****Indicates P ≤ 0.0001; *Indicates P ≤ 0.05) (Photo courtesy of Scientific Reports).

Novel Programmable DNA Nanosystem Designed for Low Cost Molecular Detection

Based in a novel way on the self-assembly forces between DNA complementary strands, researcher have developed programmable nanosystem that has now been applied in a proof-of-principle study on Ebola virus diagnosis potential. More...
05 Jul 2016
Image: The biosensor chip - consisting of a double stranded DNA probe embedded onto a graphene transistor - electronically detects DNA SNPs (Photo courtesy of the University of California, San Diego).

Biochip Combines Graphene Electronics and DNA Strand Displacement for Detection of Polymorphism Mutations

A team of bioengineers has designed an electronic biochip with potential applications for personalized medicine that can detect DNA mutations caused by single nucleotide polymorphisms (SNPs) in real time. More...
05 Jul 2016
Image: A micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumor beyond the lymph node. H&E stain. The dark purple (center) is lymphocytes (part of a normal lymph node). Surrounding the lymphocytes and extending into the surrounding fat (top of image) is ductal breast carcinoma (Photo courtesy of Michael Bonert / Wikimedia).

Artificial Intelligence Achieves Near-Human Performance in Image Analysis

A research team has developed an artificial intelligence (AI) method that trains computers to interpret pathology images. In a recent test of the method developed to examine images of lymph nodes, human complemented with computer analyses together identified breast cancer with 99.5% accuracy. More...
27 Jun 2016
Image: The MammaTyper in vitro diagnostic test kit for breast cancer subtyping (Photo courtesy of BioNTech Diagnostics).

PCR Better at Identifying Breast Tumor Subtypes than Immunohistochemistry

A recently published study suggested that a RT-qPCR (reverse transcription quantitative real-time polymerase chain reaction) assay was superior to classical immunohistochemistry for subtyping breast tumors. More...
27 Jun 2016
Image: A colorized scanning electron micrograph (SEM) showing a number of Gram-negative Escherichia coli bacteria of the strain O157:H7 (Photo courtesy of the CDC).

Nanoscale Biosensor for Detection of Pathogenic Bacteria under Field Conditions

A team of bioengineers used nanoscale technology to develop a simple, portable biosensor system for detection of pathogenic bacteria – such as the diarrhea-causing Escherichia coli (E. coli) 0157:H7 – under field conditions. More...
27 Jun 2016
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LabMedica's Lab Technology channel informs on laboratory medicine techniques, while keeping an eye on new hardware, LIM software, consumables, and lab trends, techniques and safety.
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