We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GENRUI BIOTECH INC.

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
03 Mar 2021 - 05 Mar 2021
Virtual Venue
06 Mar 2021 - 10 Mar 2021
Virtual Venue

Paper Diagnostic Directly Measures Fibrinogen in Whole Blood

By LabMedica International staff writers
Posted on 10 Nov 2020
Print article
Image: Fibrinogen Test: people with low fibrinogen levels show a rapid movement of blood up the device (Photo courtesy of Monash University).
Image: Fibrinogen Test: people with low fibrinogen levels show a rapid movement of blood up the device (Photo courtesy of Monash University).
Fibrinogen is a protein found in blood that is needed for clotting. When a patient experiences traumatic injury, such as a serious car accident, or major surgery and childbirth complications, fibrinogen is required in their blood to prevent major hemorrhaging and death from blood loss.

Typically, heavily bleeding patients must be transported to a hospital or emergency center where they undergo diagnostic tests before being treated. These tests are time consuming and costly as they require expensive equipment, specialized or trained personnel and can take up to half an hour. More than 20% of major trauma patients have hyperfibrinogenemia.

Chemical Engineers at Monash University (Clayton, Australia) developed a handheld fibrinogen diagnostic device that works with whole blood. The test works by placing a pre-mixed droplet of a blood sample and an enzyme solution onto a solid surface, allowing it to clot, and then dropping a paper strip on top. The further that blood moves down the strip of paper, the lower the fibrinogen concentration. The diagnostic can work with a variety of blood conditions. Furthermore, diluting blood samples not only increases the test's sensitivity, but also eliminates the effect of interfering substances in the blood.

The further that blood moves down the strip, the lower the fibrinogen concentration. The diagnostic can easily measure plasma fibrinogen concentrations below 1.6 g/L for blood samples with hematocrits between 40 and 50%. The test can be completed in 3 to 4 minutes, making it suitable for diagnosing early hypofibrinogenemia and allowing for fibrinogen replacement therapy in critically bleeding patients.

Gil Garnier, PhD, a Professor of Chemical Engineering and senior author of the study, said, “This diagnostic will allow emergency doctors and paramedics to quickly and accurately diagnose low levels of fibrinogen in patients, giving them faster access to life-saving treatment to stop critical bleeding. When a patient is bleeding heavily and has received several blood transfusions, their levels of fibrinogen drop. Even after dozens of transfusions, patients keep bleeding. What they need is an injection of fibrinogen. However, if patients receive too much fibrinogen, they can also die.” The study was published on October 23, 2020 in the journal ACS Sensors.

Related Links:
Monash University

Gold Supplier
Blood Glucose Laboratory Analyzer
Nova Primary
New
Gold Supplier
Clinical Chemistry Series
Clinical Chemistry Series
New
Gold Supplier
Nucleic Acid Extractor (Magnetic Bead Method)
Singu20
New
Silver Supplier
Nucleic Acid Extractor
Pre-NAT II

Print article

Channels

Molecular Diagnostics

view channel
Image: Micrograph of a colorectal adenocarcinoma (Photo courtesy of Wikimedia Commons)

Plasma or Urine Liquid Biopsy Tests May Guide Colorectal Cancer Treatment

A recent paper suggested that liquid biopsy examination of blood or urine could aid in evaluating the effectiveness of therapy for colorectal cancers that had begun to metastasize beyond the site of the... Read more

Industry

view channel
Image: Sysmex CN-Series automated blood coagulation analyzer (Photo courtesy of Sysmex Corporation)

Siemens and Sysmex Extend Agreement to Provide One of the Largest Portfolios of Hemostasis Testing Systems and Reagents

Siemens Healthineers (Erlangen, Germany) and Sysmex Corporation (Kobe, Japan) have renewed their long-standing global supply, distributorship, sales and service agreement for a broad portfolio of hemostasis... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.