We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

QuidelOrtho

Develops, manufactures and markets rapid diagnostic tests that focus on infectious diseases, reproductive health, and... read more Featured Products: More products

Download Mobile App




Novel Adipokine Biomarker Reported for Insulin Resistance and Atherosclerosis

By LabMedica International staff writers
Posted on 21 Jul 2021
Diabetes Mellitus is a chronic condition occurring due to inadequate production or inadequate action of insulin, ultimately leading to hyperglycemia. More...
Prediabetes, regarded as a precursor of diabetes, is a condition with elevated plasma glucose above normal levels, but below that of clinical disease.

Atherosclerotic cardiovascular diseases contribute to the world’s largest disease burden and are a leading cause of morbidity and mortality in both diabetics and prediabetics, accounting for about two third of mortality in diabetics. Increased levels of adipose derived cytokine (adipokine) apart from having immunological role, also have role in insulin resistant states and the process of atherosclerosis.

Medical Scientists at the Dr. Ram Manohar Lohia Hospital (New Delhi, India) included in a case control study 60 prediabetic patients and 60 age, sex, BMI matched controls. In both cases and controls serum levels of fasting and postprandial blood glucose, glycated hemoglobin (HbA1c) using a Vitros dry chemistry analyzer (Ortho Clinical Diagnostics, Bridgend, UK) and fasting insulin levels were measured by Chemiluminescence Immuno Assay (CLIA) on Vitros ECiQ. Homeostatic model assessment of insulin resistance (HOMA-IR) values in both the groups was calculated using fasting glucose and insulin levels. Serum Retinol Binding Protein-4 (RBP4) levels were measured using ELISA (IMMUNDIAGNOSTIK AG, Bensheim, Germany). The values obtained were compared between cases and controls. Carotid Intima-Media Thickness (CIMT) was only measured in cases using B-mode ultrasonography.

The investigators reported that the Median (IQR) of fasting plasma insulin levels (uIU/ml) in cases was 11.3 versus that of controls which was 5.73. HOMA-IR median (IQR) in cases and controls was 3.12 and 1.21 respectively. Median (IQR) for RBP4 in cases was 67.4 which were significantly higher as compared to controls 33.92. Significant positive correlation was seen between RBP4 with both, HOMA-IR and mean CIMT with correlation coefficients of 0.3693 and 0.621 respectively. On performing univariate linear regression analysis it was found that with increase in serum RBP4 levels by 1 mg/L, HOMA-IR and mean CIMT significantly increased by 0.007 units and 0.001 mm respectively.

The authors concluded prediabetics have been found to have more risk of cardiovascular events as compared to normoglycemics. Early assessment of the same with the use of novel biomarkers like RBP4 can be considered for early detection of atherosclerosis in prediabetic individuals. The study was published in the July 2021 issue of the Journal of the Association of Physicians of India.

Related Links:
Dr. Ram Manohar Lohia Hospital
Ortho Clinical Diagnostics
IMMUNDIAGNOSTIK AG



Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Candida Glabrata Test
ELIchrom Glabrata
New
Silver Member
Fibrinolysis Assay
HemosIL Fibrinolysis Assay Panel
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: The RNA-seq based diagnostic test for pediatric leukemia ensures better outcomes for children with this common cancer (Photo courtesy of Qlucore)

RNA-Seq Based Diagnostic Test Enhances Diagnostic Accuracy of Pediatric Leukemia

A new unique test is set to reshape the way Acute Lymphoblastic Leukemia (BCP-ALL) samples can be analyzed. Qlucore (Lund, Sweden) has launched the first CE-marked RNA-seq based diagnostic test for pediatric... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.