Online Cancer Database Speeds Drug Discovery Process

The Cancer Research UK-funded database--known as canSAR--has been set up by researchers at Cancer Research UK's Center for Cancer Therapeutics at The Institute of Cancer Research (ICR; London) to create a one-stop-shop for scientists worldwide. For the first time, it brings together all the relevant biological, chemical, pharmacological, and eventually clinical data about important genes and proteins in every type of cancer in a way that greatly aids the discovery of new drugs.

The freely available database allows scientists and clinicians to search through cancer-related data and information across the spectrum of research--from genomics to clinical trials--in a portion of the time it would earlier have taken them to collected this information.

Dr. Bissan Al-Lazikani, an ICR scientist who led the research team that developed canSAR, stated, "With the unprecedented amounts of electronic data being generated by modern molecular research techniques, the demand for a resource that brings together all this information and makes it available in a clear and manageable format is greater than ever. Previously the information was stored in many different locations and formats, which limited its effective use by researchers.”

Prof. Paul Workman, director of the Cancer Research UK Center for Cancer Therapeutics at the ICR, said, "We have already found canSAR to be fantastically useful in our own cancer drug discovery research. We are applying it to evaluate large number of potential drug targets in a faster and more systematic way than before and to select the best ones to work on. Having road tested it ourselves, I'm really excited about our powerful canSAR tool and I'm delighted to make it available to the cancer research community worldwide. Scientists can now, at the click of a button and at a single online location, rapidly identify the biological and structural characteristics of an actual or potential drug target, find the genes and proteins that it interacts with, assess its structural drugability and identify any small molecule chemical inhibitors. Researchers can also find information on the cancer cell lines that are most suitable for their experiments. This information is now available in minutes whereas it would previously have taken weeks to find.”

canSAR contains information on the entire human proteome--the protein equivalent of the human genome--as well as linking to data on more than 1,000 cancer cells lines, utilized by researchers to study the effect of new drugs in the lab. Significantly, scientists will also have improved access to information about all the chemical compounds known to be active on a particular drug target--tying the biology and chemistry together in a new way.

"For example, one can quickly look at data on 700,000 chemical compounds acting on 4,000 molecular targets. It contains a total of more than eight million experimental data points. Patients will benefit because researchers will be able to move more quickly from a basic research discovery to new drugs in the clinic,” added Prof. Workman.

Dr. Lesley Walker, Cancer Research UK's director of cancer information, said, "This new database will provide scientists with easy access to research being carried out by other specialist groups around the world, paving the way for a much more collaborative way of working. Hopefully, this will help accelerate the pace at which discoveries involving the nuts and bolts of cancer can be translated into effective new drugs in the clinic. I'd encourage all researchers to take advantage of this important resource.”

canSAR v1.0 can be accessed online (please see Related Links below), and is an integrated database and workbench that brings together biologic, chemical, pharmacologic (and ultimately clinical), data. Its goal is to integrate this information and make it accessible to cancer research scientists from multiple disciplines worldwide, in order to help with hypothesis generation in cancer research, and support drug discovery decisions.

Users can search canSAR using text queries, protein/gene name searches, any keyword searches, chemical structure searches, and sequence similarity searches. Moreover, users can explore and filter chemical compound sets, view experimental data, and produce summary plots.

Related Links:
Cancer Research UK
canSAR v1.0