We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Sekisui Diagnostics

Download Mobile App




Blocking Key Fat Metabolic Enzyme Lowers Blood Triglyceride Levels

By LabMedica International staff writers
Posted on 15 Mar 2010
Inhibition of a key enzyme of fat metabolism lowers serum triglyceride levels and reduces amounts of cardiovascular disease risk indicators such as apolipoprotein B while increasing insulin sensitivity and glucose tolerance.

Excessive accumulation of triglycerides in peripheral tissues is closely associated with obesity and has been identified as an independent risk factor for insulin resistance, type II diabetes, and cardiovascular complications. More...
Triglycerides are released into the blood stream through the action of the enzyme triacylglycerol hydrolase (TGH, also known as carboxylesterase-3, Ces3). In the current study, investigators from the University of Alberta (Edmonton, Canada) sought to improve the blood lipid profile by inhibiting the activity of TGH.

The investigators genetically engineered a line of mice to lack the gene for TGH. They reported in the March 3, 2010, edition of the journal Cell Metabolism that these TGH-null animals showed decreased plasma triglycerides, apolipoprotein B, and fatty acid levels in both fasted and fed states. These mice exhibited increased food intake and energy expenditure without change in body weight, and these metabolic changes were accompanied by improved insulin sensitivity and glucose tolerance. Despite a reduction in the level of very low-density lipoprotein (VLDL) secretion, TGH deficiency did not increase the amount of triglycerides in the animals' livers.

The authors concluded that, "These studies demonstrate the potential of TGH as a therapeutic target for lowering blood lipid levels.”

Related Links:
University of Alberta



Platinum Member
Automated Coagulation Analyzer
Hemolumi H6
New
Gold Member
Serum Indices Control
Acusera Serum Indices Control
Automated Clinical Chemistry Analyzer
Envoy 500+
Platinum Member
Integrated Biochemical & Immunological System
Biolumi CX Solution X10+C10
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image Credit: 123RF

Screening After Pneumococcal Disease May Reveal Undiagnosed Blood Cancer or Immune Disorders

Severe pneumococcal disease requiring hospitalization often presents as pneumonia, particularly in older adults and people with cancer or compromised immune function. Because M protein testing and antibody... Read more

Microbiology

view channel
Image Credit: 123RF

FDA-Cleared Multiplex PCR Test Detects 13 Respiratory Pathogens in a Single Sample

Respiratory tract infections can be difficult to distinguish at presentation because many cause overlapping, nonspecific symptoms and are initially grouped as influenza-like illnesses. Causes span a range... Read more

Technology

view channel
Image: The laser-based photoacoustic spectroscopy setup consists of a Mid-IR laser equipped with three QCL modules covering wavelengths from 5.6 μm to 12.9 μm, two silver coated mirrors (SCM), a dichroic mirror (DM) with a transmittance of 90%, a thermal power sensor head (PM) to monitor the output laser power, a mechanical chopper (MC) for frequency modulation and a CEPAS-detector with a self-designed swab holder (SH). (Credit: Graunke, T., Scholz, T., Pieniak, M. et al. Scientific Reports (2026). https://doi.org/10.1038/s41598-026-68298-9)

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Industry

view channel
Image

Collaboration Combines AI Cognitive Assessment and RNA Blood Testing for Earlier Alzheimer’s Detection

Alzheimer’s disease is often identified only after substantial neurodegeneration, partly because current diagnostic pathways are fragmented and difficult to scale. As treatment shifts toward earlier intervention,... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.