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Clinical Chemistry

Image: The lab-on-a-chip device integrates a fiber optic biosensor with a microfluidic chip and detects glucose levels from droplets of sweat. It is shown here next to a Hong Kong dollar, which is the same size as the USD coin (Photo courtesy of Dr. A. Ping Zhang).

Microfluidic Chip Developed For Ultrasensitive Glucose Detection

Highly sensitive and rapid detection of blood glucose is a diagnostic necessity in medicine as, for instance, lack of insulin and too much blood sugar are two main causes of diabetes, both of which can be detected by measuring blood glucose. More...
18 May 2016
Image: The Varian Scimitar Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy instrument (Photo courtesy of S. Levchenkov).

Infrared Technology Used To Screen For Minimally Invasive Colitis

Inflammatory bowel diseases, which include ulcerative colitis and Crohn's disease, involve chronic inflammation of all or part of the digestive tract and can lead to life-threatening complications such as colorectal cancer. More...
18 May 2016
Image: Dried blood spots are used to screen newborns for a number of rare inherited conditions. A new dried blood spot screening test has been developed for Niemann-Pick type C, a rare neurodegenerative condition that usually is not diagnosed until after damage to brain cells has begun (Photo courtesy of Washington University School of Medicine).

Newborn Screening Test Developed For Deadly Neurological Disorder

A newborn screening test has been introduced that identifies infants with Niemann-Pick disease type C, an often fatal condition in which cholesterol builds up and eventually destroys brain cells. More...
18 May 2016

Breath Test May Help Diagnose Irritable Bowel Syndrome

There is currently no specific diagnostic & monitoring test for irritable bowel syndrome (IBS) and no potentially reliable biomarkers have been identified until now. Using a novel metabolomic approach, researchers have identified a combination of substances in the breath that, when measured together, accurately distinguished IBS patients from people without the condition. More...
17 May 2016
Image: The MRX microplate reader (Photo courtesy of Dynatech Medical Products).

Blood Test Detects Breast Cancer Spread Earlier

More sensitive, non-invasive tests are required for secondary breast cancer, which occurs when new tumors grow in the bone, liver, lung or brain, to make diagnosis easier and for treatment to begin as early as possible. More...
12 May 2016

Blood Test Developed for Parkinson’s Disease

Currently no clinical biomarker test exists for Parkinson's and the only means of diagnosis is a neurological examination and by the time patients develop symptoms and undergo the examination, large numbers of vital brain cells have already been destroyed. More...
12 May 2016

New Approach Improves Identification of Women at High Risk of Preeclampsia

A new meta-analysis examining 92 cohort studies involving over 25 million pregnancies has provided an unprecedented understanding of risk factors for preeclampsia—some risk factors being strong enough to warrant that a pregnant woman starts on prophylactic treatment with acetylsalicylic acid (ASA) when she has only one. More...
05 May 2016
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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