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Clinical Chemistry

Image: The Easy-nLC 1000 liquid chromatography system (Photo courtesy of Thermo Fisher Scientific).

Phosphoproteins Identified as Biomarkers for Cancer

The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins in biofluids for disease diagnosis remains elusive. More...
05 Apr 2017

Simple Urine Test Helps Track ALS Progression

The continued failure of amyotrophic lateral sclerosis (ALS) clinical trials and the absence of therapeutic options for this fatal disease have fueled interest in the prospect that biomarkers may hold great promise for advancing therapy development efforts. More...
05 Apr 2017
Image: The Combur 10 urinalysis test strips (Photo courtesy of Roche).

Early Serum Creatinine Predicts Post-Surgery AKI

Acute Kidney Injury (AKI) is a common and serious complication of cardiac surgery. Mild AKI occurs in nearly one in five patients undergoing cardiac surgery and is associated with a 19-fold increase in short-term mortality. More...
05 Apr 2017
Image: A transmission electron micrograph (TEM) of a mesenchymal stem cell displaying typical ultrastructural characteristics (Photo courtesy of Robert M. Hunt).

Organ Cells Derived from Stem Cells May Predict Drug Sensitivity

Testing the drug pazopanib on liver-like cells derived from patient-specific stem cells, researchers have shown first proof-of-concept for a new approach that could lead to development of personalized drug-toxicity assays for patients. More...
29 Mar 2017
Image: A diagram of the wearable sweat-monitoring patch. A porous sweat-uptake layer is placed on a Nafion layer and sensors (Photo courtesy of the Institute for Basic Science).

Wearable Glucose Device Includes Drug-Delivery Module

Researchers have developed a convenient accurate sweat-based glucose monitoring and maintenance device that provides rapid glucose measurement and allows doctors to prescribe a multistep precisely controlled dosage of drugs. More...
24 Mar 2017
Image: Researchers are using plasma ceramides as a new biomarker of unstable atherosclerotic cardiovascular disease (Photo courtesy of the Mayo Clinic).

Testing for Ceramides Helps Predict Cardiovascular Events

Researchers have found that measuring blood concentrations of the ceramides class of lipids can help predict high risk of cardiac events even for people with low LDL or no evidence of heart blockages, thus helping clinicians identify individuals with suspected coronary heart disease. More...
23 Mar 2017
Image: The Quo-Test analyzer (Photo courtesy of EKF Diagnostics).

Study Reaffirms HbA1c Analyzer Meets Performance Standards

In a newly published paper, a point-of-care (POC) hemoglobin A1c (HbA1c) analyzer has again been confirmed to meet the performance criteria of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). More...
10 Mar 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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