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Clinical Chemistry

Image: The LUMIPULSE G1200 is a robust mid-sized fully automated immunoassay instrument (Photo courtesy of Fujirebio Diagnostics).

Novel Procalcitonin Immunoassay Analytically Evaluated

The exact definition of sepsis has changed considerably over time, and remains controversial. This is probably due to the fact that sepsis develops as a continuum of severity, ranging from local infection, through bloodstream propagation to septic shock. More...
25 Jan 2017
Image: The M40 automatic chemistry analyzer for HbA1c (Photo courtesy of Hitachi).

Positive Fecal Occult Blood Test Associated with Diabetes

Numerous etiologies are implicated in the complications of diabetes and a link between diabetes and the predisposition to certain cancers, including colon cancer, has been established during the last decade. More...
25 Jan 2017
Image: A ball-and-stick model of the testosterone molecule (C19H28O2) as found in the crystal structure of testosterone monohydrate (Photo courtesy of Wikimedia).

New Defined Reference Range for Testosterone Levels Established

Through a landmark study based on cohorts in the USA and Europe, researchers have established a harmonized reference range for testosterone levels in men to help limit misdiagnoses and unnecessary treatments. This can be particularly helpful in identifying patients with hypogonadism, as the lack of both defined reference ranges of testosterone and of standardization of hormone assays has made diagnosing hypogonadism a difficult task. More...
24 Jan 2017
Image: A micrograph showing cells with abnormal p53 expression (brown) in a brain tumor (Photo courtesy of Wikimedia Commons).

Novel Biosensor Selectively Measures Cancer Patient p53 Autoantibodies

A team of Spanish cancer researchers has developed a disposable electrochemical biosensor for the specific and sensitive determination of p53-specific autoantibodies, which are biomarkers for certain types of cancers with p53 gene mutations. More...
24 Jan 2017
Image: Only a few microliters of tears are needed to analyze the vitamins in them (Photo courtesy of Sarah Bird, Michigan Technological University).

Comparison of Vitamin Concentrations in Tears and Serum

Results obtained during a recent study suggest that tears could be used as specimens to monitor nutritional health, since they are easily obtained, sufficiently mirror blood serum data, and enhance the speed of deficiency diagnoses. More...
24 Jan 2017
Image: The ARCHITECT C4000 chemical analyzer (Photo courtesy of Abbott Laboratories).

Blood Test Predicts Silent Heart Disease Risk

Coronary heart disease is the UK's single biggest killer, accounting for nearly 70,000 deaths in the UK each year. When heart muscle is damaged it leaks a protein called troponin in to the blood stream. Patients suspected of suffering a heart attack will often be given a troponin test to aide diagnosis, but until now the test has not been used to assess future heart attack risk. More...
19 Jan 2017
Image: The C-DiGit blot scanner (Photo courtesy of Li-Cor BioTech).

Early Biomarker Found for Sepsis-Induced Kidney Injury

Sepsis is a worldwide health care problem and a leading cause of death of patients in intensive care unit. On the other hand, acute kidney injury (AKI) is a clinical syndrome of an abrupt renal dysfunction leading to uremic toxins accumulation and several organs dysfunction. More...
19 Jan 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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