We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Proteomic Noninvasive Biomarkers Associated with Sport-Related Concussions

By LabMedica International staff writers
Posted on 26 Jan 2022
Print article
Image: Proteomic Noninvasive Biomarkers Discovered Associated with Sport-Related Concussions (Photo courtesy of The Lancet)
Image: Proteomic Noninvasive Biomarkers Discovered Associated with Sport-Related Concussions (Photo courtesy of The Lancet)
Sport-related concussions affect millions of individuals across the USA each year, and current techniques to diagnose and monitor them rely largely on subjective measures. Concussion can be frustratingly hard to diagnose and track.

The injury does not show up on routine brain scans, and there is no definitive diagnostic test. It’s usually diagnosed based on symptoms, and, in athletes, comparison with baseline testing if it was done, but concussion symptoms are non-specific, unreliable, and easily influenced by emotions.

A multidisciplinary team of clinical scientists led by those at Boston Children’s Hospital (Boston, MA, USA) included in a study 48 control and 47 age- and sex-matched athletes with concussion were included in the study (51.6% female, 48.4% male, mean age 19.6 years). Urine samples from a convenience series of healthy control collegiate athletes who had not sustained a concussion and athletes who sustained a concussion as diagnosed by a sports medicine physician within seven days were collected prospectively and studied. All but one of the post-concussion participants reported experiencing symptoms at the time of data collection.

The scientists used Tandem Mass Tags (TMT) mass spectroscopy and ELISA, to identify and validate urinary biomarkers of concussion. They reported that Insulin-like growth factor 1 (IGF-1) and IGF binding protein 5 (IGFBP5) were downregulated in the urine of athletes with concussions compared to healthy controls. Multivariable risk algorithms developed to predict the probability of sport-related concussion showed that IGF-1 multiplexed with single-task gait velocity predicts concussion risk across a range of post-injury time points (area under the curve [AUC] 0.786). When IGF-1 and IGFBP5 are multiplexed with single-task gait velocity, they accurately distinguish between healthy controls and individuals with concussion at acute time points (AUC 0.835).

Marsha A. Moses, PhD, director of the Vascular Biology Program and the senior author of the study, said, “In many illnesses, markers of physical and biological damage find their way into the bloodstream, and can often be found in the urine. Urine testing can be done early and often and is inexpensive compared to other types of tests.”

The authors concluded that these noninvasive biomarkers, discovered in an objective and validated manner, may be useful in diagnosing and monitoring sport-related concussions in both acute phases of injury and several days after injury. The study was published on January 11, 2021 in the journal Neurology.

Related Links:
Boston Children’s Hospital

Gold Supplier
SARS-CoV-2 Antigen Test
NG-Test SARS-NG-Test SARS-CoV-2 Ag Cassette
3-DIFF Hematology Analyzer
Urine Analyzer
Automated Nucleic Acid Extraction System

Print article


Clinical Chem.

view channel
Image: The analysis pipeline used to investigate associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease (Photo courtesy of University College London)

Lipid Measurements Show Potential as Alzheimer’s Disease Biomarkers

Brain changes accompanying ageing are varied and can include pathologies that lead to cognitive impairment, the commonest of which is Alzheimer’s disease (AD). Identifying blood-based signatures of brain... Read more

Molecular Diagnostics

view channel
Image: This image depicts a DNA molecule that is methylated on both strands on the center cytosine. DNA methylation plays an important role for epigenetic gene regulation in development and cancer (Photo courtesy of Wikimedia Commons)

Study Supports Use of Methylated DNA Biomarkers for Cancer Diagnosis and Prognosis

A recent study added weight to the theory that methylated DNA biomarkers could be used for cancer diagnosis and prognosis. Methylation is a biological process by which methyl groups are added to a DNA molecule.... Read more


view channel
Image: Standard test for multiple myeloma provides clues of a rare, more deadly type (Photo courtesy of Pexels)

Standard Blood Cancer Test Provides Clues of Rare IgD Multiple Myeloma

IgD myeloma accounts for about 1% of common blood cancer multiple myeloma and has a worse prognosis. Specific testing for IgD myeloma is available at a handful of reference labs across the US, but takes... Read more


view channel
Image: QIAGEN has acquired a majority stake in enzymes provider BLIRT S.A. (Photo courtesy of QIAGEN)

Qiagen Acquires Enzymes Provider Blirt to Strengthen Sample Technologies Business

QIAGEN N.V. (Venlo, Netherlands) has signed agreements to acquire a 96% majority ownership stake in BLIRT S.A. (Gdansk, Poland), a manufacturer of recombinant enzymes for the life science industry.... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.