We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Non-Invasive Blood Test for Endometriosis Could Replace Surgical Procedures

By LabMedica International staff writers
Posted on 04 Aug 2025

Endometriosis affects 6. More...

5 million women in the United States and remains notoriously difficult to diagnose, with patients waiting an average of seven years for a definitive diagnosis. The current diagnostic standard—laparoscopic surgery—is invasive, expensive, and carries inherent risks and side effects. This delay in diagnosis often forces women to endure severe pelvic pain, painful intercourse, fatigue, and infertility without proper treatment. Many patients are told their symptoms are normal, even when they are experiencing disabling pain. The lack of a simple, non-invasive diagnostic method has led to misdiagnosis or no diagnosis at all for countless women. Now, a new blood-based test offers a quicker, safer, and more accessible pathway to diagnosing endometriosis, potentially transforming patient care.

The EndomTest, developed by Kephera Diagnostics (Framingham, MA, USA), measures two specific biomarkers, Brain Derived Neurotrophic Factor (BDNF) and Cancer Antigen 125 (CA125), in human serum and combines them with clinical variables using a proprietary algorithm to provide a rule-in diagnostic result. Both BDNF and CA125 have been shown in studies to be elevated in the serum of patients with endometriosis versus healthy controls. While each individual biomarker is not 100% specific to endometriosis, the combined measurements of the levels of both biomarkers together with selected patient history information was found to yield a highly specific assay for endometriosis, suitable as a “rule in” test. The test requires only a blood sample, offering a non-surgical diagnostic option for patients.

With the EndomTest, clinicians now have a non-invasive blood test for endometriosis that offers an attractive alternative to laparoscopy—an invasive procedure with risks common to surgeries, including the potential for post-surgical complications. Published clinical validation studies demonstrate that EndomTest delivers 100% specificity, meaning no false positives were reported in the methodology used. The specificity of the test means that a positive result provides a patient with certainty about their condition. This high accuracy can inform critical treatment decisions, including whether surgery is necessary, and support earlier treatment options for patients. The test is expected to fill critical gaps in women's healthcare by providing a reliable and accessible alternative to surgical diagnosis for endometriosis.

“We are proud to be launching the first non-invasive test for endometriosis in the United States. EndomTest leverages Kephera’s scientific expertise in in-vitro assays for challenging diseases. With the launch of this test through our CLIA lab, we hope to provide a diagnostic solution that will improve healthcare for thousands of patients who are affected by endometriosis,” said Andrew Levin, Chief Executive and Scientific Officer, Kephera Diagnostics.

Related Links:
Kephera Diagnostics


New
Gold Member
Immunochromatographic Assay
CRYPTO Cassette
POC Helicobacter Pylori Test Kit
Hepy Urease Test
New
Alcohol Testing Device
Dräger Alcotest 7000
New
Silver Member
Rapid Test Reader
DIA5000
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The test could streamline clinical decision-making by identifying ideal candidates for immunotherapy upfront (Xiao, Y. et al. Cancer Biology & Medicine July 2025, 20250038)

Blood Test Predicts Immunotherapy Efficacy in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies, making immunotherapy a promising yet unpredictable option. Current biomarkers such as PD-L1 expression or tumor... Read more

Microbiology

view channel
Image: New diagnostics could predict a woman’s risk of a common sexually transmitted infection (Photo courtesy of 123RF)

New Markers Could Predict Risk of Severe Chlamydia Infection

Chlamydia trachomatis is a common sexually transmitted infection that can cause pelvic inflammatory disease, infertility, and other reproductive complications when it spreads to the upper genital tract.... Read more

Pathology

view channel
image: Researchers Marco Gustav (right) and MD Nic G. Reitsam (left) discuss the study data (Photo courtesy of Anja Stübner/EKFZ)

AI Model Simultaneously Detects Multiple Genetic Colorectal Cancer Markers in Tissue Samples

Colorectal cancer is a complex disease influenced by multiple genetic alterations. Traditionally, studies and diagnostic tools have focused on predicting only one mutation at a time, overlooking the interplay... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.