We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
BIO-RAD LABORATORIES

Download Mobile App





Several Biomarkers Predict Progression of SARS-CoV-2 Infection

By LabMedica International staff writers
Posted on 05 Sep 2022
Print article
Image: MeMed Key is a multi-purpose immunoassay platform for quantitative diagnostic immunoassays that opens the way to central laboratory performance at the point-of-need, using chemiluminescence detection technology (Photo courtesy of MeMed)
Image: MeMed Key is a multi-purpose immunoassay platform for quantitative diagnostic immunoassays that opens the way to central laboratory performance at the point-of-need, using chemiluminescence detection technology (Photo courtesy of MeMed)

After two years into the pandemic, COVID-19 still poses an imminent global threat. Although most infections remain asymptomatic or cause only mild symptoms, severe cases are still causing significant morbidity and mortality.

On the basis of current knowledge, hyperinflammation plays a critical role in disease progression and clinical deterioration, suggesting that measurements of immune-based biomarkers represent promising tools for the early detection of the likelihood to deteriorate. These parameters can be available within minutes through point-of-care testing, and the insights provided by immune biomarkers might facilitate and accelerate diagnostic work-up.

Medical Microbiologists at Saarland University (Homburg, Germany) recruited into a study 132 patients (mean age 64 years, 40.2% females) who had a polymerase chain reaction (PCR)–confirmed infection with SARS-CoV-2 (except for controls) during the second and third pandemic wave experienced in Germany (December 2020 to July 2021). The control group consisted of 27 adults (mean age 47.1 years, range 22-83; 19 [70.4%] females), composed of 19 adults in group 1 and eight adults in group 2. Nasopharyngeal swabs, blood samples, and SARS-CoV-2 RT-PCR were routinely performed on admission and regularly throughout the hospital stay to account for dynamic changes in biomarker levels over time.

The investigators used a novel platform MeMed Key (MeMed, Tirat Carmel, Israel) that measures the circulating levels of the three host response immune proteins: TNF-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP). The method is based on a chemiluminescent immunoassay. Levels of TRAIL, IP-10, and CRP were measured at the study site in serum samples.

The scientists performed a total of 899 measurements. Among patients with COVID-19, TRAIL levels were significantly lower (49.5 versus 87 pg/mL), whereas IP-10 and CRP showed significantly higher levels (667.5 versus 127 pg/mL), and 75.3 versus 1.6 mg/L) than healthy controls. TRAIL yielded an inverse correlation with length of hospital and intensive care unit (ICU) stay, Simplified Acute Physiology Score II, and National Early Warning Score, and IP-10 showed a positive correlation with disease severity. Multivariable regression revealed that obesity (adjusted odds ratio [aOR] 5.434), CRP (aOR 1.014), and peak IP-10 (aOR 1.001) were independent predictors of in-ICU mortality.

The authors concluded that TRAIL and IP-10 showed significant correlation with COVID-19 severity, and CRP and IP-10 levels were associated with adverse COVID-19 outcomes. This suggests that the inclusion of these markers into multivariable risk assessment models could be a promising tool in the management of patients with COVID-19. The study was published on September 1, 2022 in the International Journal of Infectious Diseases.

Related Links:
Saarland University 
MeMed 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
POCT Fluorescent Immunoassay Analyzer
FIA Go
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: The novel test uses an existing diagnostic procedure as its basis to target the Epstein Barr Virus (Photo courtesy of 123RF)

Blood Test Measures Immune Response to Epstein-Barr Virus in MS Patients

Multiple sclerosis (MS) is a chronic neurological condition for which there is currently no cure. It affects around three million people globally and ranks as the second most common cause of disability... Read more

Microbiology

view channel
Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)

Integrated Solution Ushers New Era of Automated Tuberculosis Testing

Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more

Pathology

view channel
Image: Insulin proteins clumping together (Photo courtesy of Jacob Kæstel-Hansen)

AI Tool Detects Tiny Protein Clumps in Microscopy Images in Real-Time

Over 55 million individuals worldwide suffer from dementia-related diseases like Alzheimer's and Parkinson's. These conditions are caused by the clumping together of the smallest building blocks in the... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.