We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
Sekisui Diagnostics

Download Mobile App




Automated Cell Migration System to Boost Drug Development Efforts

By LabMedica International staff writers
Posted on 01 Jun 2010
An add-on module for an integrated microscope/incubator system has recently been introduced into the market that makes it practical to study all aspects of cell migration and especially how it is affected by candidate drug compounds.

Cell migration is a multistep process that is a fundamental component of many important biological and pathological processes such as embryonic development, tissue reorganization, angiogenesis, immune cell trafficking, chronic inflammation, and tumor metastasis. More...
Cell migration is initiated by a stimulus that activates a set of signaling pathways leading to cellular polarization and a rapid reorganization of actin filaments and microtubules.

Cells advance by protruding their membrane at their leading cell border, which is followed by dynamic substrate adhesion via integrin adherence to the substrate. Membrane retraction at the lagging cell edge finishes the cycle, which is then repeated in rapid succession. The migration process is terminated when the stimulus to migrate is extinguished. In general, cell migration assays are well suited for both drug discovery and pathway analysis because they are rapid, reproducible, and can be adapted for use with many different cell types

Essen BioScience Inc. (Ann Arbor, MI, USA) recently released its CellPlayer Cell Migration 96-well assay kit as an add-on to its IncuCyte Live-Cell Imaging System. IncuCyte is a compact automated microscope that resides inside a standard tissue culture incubator.

The CellPlayer Cell Migration 96-well assay offers a precise and reproducible label-free method for monitoring the key biological processes involved in cell migration. This kinetic assay features automated data collection over a period of hours or days and generates data sets that are optimal for studying pharmacological agents and gene silencing technologies for this important function. Software built-in to IncuCyte automates the data collection process and provides the subsequent analysis for the cell migration assay.

Researchers not wishing to purchase a cell migration monitoring system can have samples evaluated by Essen's in-house service laboratory.

Related Links:
Essen BioScience Inc.




Platinum Member
Automated Coagulation Analyzer
Hemolumi H6
Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
New
Drug Testing Assays
Atellica DT 250 Analyzer
Platinum Member
Integrated Biochemical & Immunological System
Biolumi CX Solution X10+C10
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Clinical Chemistry

view channel
Image Credit: 123RF

Screening After Pneumococcal Disease May Reveal Undiagnosed Blood Cancer or Immune Disorders

Severe pneumococcal disease requiring hospitalization often presents as pneumonia, particularly in older adults and people with cancer or compromised immune function. Because M protein testing and antibody... Read more

Microbiology

view channel
Image Credit: 123RF

FDA-Cleared Multiplex PCR Test Detects 13 Respiratory Pathogens in a Single Sample

Respiratory tract infections can be difficult to distinguish at presentation because many cause overlapping, nonspecific symptoms and are initially grouped as influenza-like illnesses. Causes span a range... Read more

Technology

view channel
Image: The laser-based photoacoustic spectroscopy setup consists of a Mid-IR laser equipped with three QCL modules covering wavelengths from 5.6 μm to 12.9 μm, two silver coated mirrors (SCM), a dichroic mirror (DM) with a transmittance of 90%, a thermal power sensor head (PM) to monitor the output laser power, a mechanical chopper (MC) for frequency modulation and a CEPAS-detector with a self-designed swab holder (SH). (Credit: Graunke, T., Scholz, T., Pieniak, M. et al. Scientific Reports (2026). https://doi.org/10.1038/s41598-026-68298-9)

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Industry

view channel
Image

Collaboration Combines AI Cognitive Assessment and RNA Blood Testing for Earlier Alzheimer’s Detection

Alzheimer’s disease is often identified only after substantial neurodegeneration, partly because current diagnostic pathways are fragmented and difficult to scale. As treatment shifts toward earlier intervention,... Read more
Copyright © 2000-2026 Globetech Media. All rights reserved.