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Pathology

Image: Schematic diagram of Molecular Characterization Identifying Distinct Molecular Hallmarks of Renal Medullary Carcinoma (Photo courtesy of University of Texas MD Anderson Cancer Center).

Rare Kidney Cancer Marked by Molecular Features

Renal medullary carcinoma is a rare cancer of the kidney that predominantly afflicts young people of African descent who carry the sickle cell trait, sickle cell disease, or other sickle hemoglobinopathies that can cause sickling of the red blood cells. More...
19 May 2020
Image: Schematic diagram of circulating tumor DNA (ctDNA) which is found in serum and plasma fractions from blood. The mechanism of ctDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized. Once ctDNA is isolated, it can be sequenced for mutational analysis (Photo courtesy of Rachel June Wong).

Blood Test Shows Promise for Predicting Cancer

Early detection of most cancers is an elusive and daunting task; nevertheless, it has remained a top priority for the cancer research community. Detecting cancer early has manifold advantages: it can increase a patient’s chances of successful treatment, prolong their survival, and substantially improve their quality of life. More...
14 May 2020
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Image: Clostridium septicum is a gram positive, spore forming, obligate anaerobic bacterium and increases the risk of colon cancer (Photo courtesy of Alchetron).

Bacterial Blood Infections Tied to Heightened Colon Cancer Risk

Colorectal cancer occurs in the colon or the rectum and it is the third most common type of cancer in the USA. Around 90% of cases occur in people aged 50 years or older. As well as age, risk factors include a family history of colorectal cancer, some genetic syndromes, obesity, and a lack of exercise, a diet low in fruit and vegetables, and inflammatory bowel disease. More...
12 May 2020
Image: Multicancer Blood Test Aids Screen for Cancer Guide Intervention (Photo courtesy of fotoquique/Depositphotos).

Multicancer Blood Test Aids Screen for Cancer Guide Intervention

As minimally invasive screening tests, liquid biopsies could help reduce cancer-specific morbidity and mortality through earlier detection. However, there is debate on how to effectively screen large populations for cancer, including individuals who do not have symptoms or history of the disease. More...
12 May 2020
Image: Histopathological micrograph of pancreatic adenocarcinoma arising in the pancreas head region (Photo courtesy of KGH).

Biomarker Data Improves Risk Prediction for Pancreatic Cancer

Pancreatic cancer risk prediction models based on clinical factors may be refined and improved by bringing in other types of data, including germline genetic risk variant and blood-based biomarker data. More...
07 May 2020
Image: The Invitrogen Qubit 1X dsDNA HS Assay Kit (Photo courtesy of Thermo Fisher Scientific).

Targeted Next-Generation Sequencing Validated for Lysosomal Storage Disorders Diagnosis

Lysosomal storage disorders (LSDs) are a group of more than 50 inherited rare disorders characterized by the accumulation of specific undegraded metabolites in the lysosomes. This overstorage is commonly caused by a deficient or absent activity of one of the many lysosomal hydrolases or, in a few cases, by the deficit of other non-enzymatic lysosomal proteins. More...
04 May 2020
Image: The nanoString nCounter: This instrument provides a simple and cost-effective solution of direct digital quantification for multiplex analysis of up to 800 known RNA, DNA, or protein targets in one tube (Photo courtesy of the Crown Institute of Genomics).

Genetic Alterations Analyzed in Pediatric Low-Grade Glioma

Low grade gliomas are brain tumors that come from two different types of brain cells known as astrocytes and oligodendrocytes. They are classified as a grade 2 tumor making them the slowest growing type of glioma in adults. More...
28 Apr 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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