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Clinical Chemistry

Image: Pittsburgh Compound B (PiB) positron emission tomography scan of a patient with Alzheimer\'s disease (AD) on the left; red and yellow show high concentrations of PiB in the brain and suggest high amounts of amyloid deposits in these areas (Photo courtesy of the University of Pittsburgh).

Serum Cholesterol Levels Linked to Cerebral Amyloidosis

The relationship between elevated cholesterol and increased risk of Alzheimer’s disease has been specifically linked to amyloid deposits in living human study participants.   More...
15 Jan 2014
Image: A nuclear magnetic resonance tube with a protein sample (Photo courtesy of Kjaergaard).

Novel Approach Predicts Outcomes in Heart Failure Patients

A new method has been identified that determines whether a patient's heart will fail, which in the future may help physicians better treat patients and tailor therapeutic interventions.  More...
07 Jan 2014
Image: FP-6200 Series Spectrofluorometer (Photo courtesy of Jasco).

Blood Spots Compared with Plasma Sample for Chitotriosidase Assay

The chitotriosidase enzyme is markedly elevated in plasma of patients with Gaucher's disease, a relatively common lysosomal storage disorder.   More...
07 Jan 2014
Image: The ETI-Max 3000 fully automated microtiter plate analyzer (Photo courtesy of DiaSorin).

Protein Biomarker Linked to Delirium Duration

A protein biomarker appears to be linked to the duration of delirium and may have important implications for refining future delirium treatment in critically ill patients in intensive care units.  More...
06 Jan 2014
Image: Histology of a bone biopsy from a patient with vitamin D deficiency and osteomalacia (Photo courtesy of the University of Washington).

Vitamin Testing in Babies Uses Tears

Identifying vitamin deficiencies in babies involves drawing blood, a disheartening experience for all involved, but a painless alternative has been developed.   More...
02 Jan 2014
Image: Quanta Master scanning spectrofluorometer (Photo courtesy of Photon Technology International).

Sensor Tracks Zinc in Cells for Prostate Cancer Diagnosis

Mobile zinc is an indispensable component of prostate physiology and the prostate contains more zinc than any other soft tissue in the body, and there is a clear correlation between total prostatic zinc levels and cancer.   More...
31 Dec 2013
Image: Orbitrap Velos Pro hybrid ion trap mass spectrometer (Photo courtesy of Thermo Scientific).

Standardized Assays Developed to Quantify Human Proteins

The feasibility of large-scale standardized protein measurements, which are necessary for validation of disease biomarkers, has been developed.    More...
30 Dec 2013
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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