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Clinical Chemistry

Image: The Access 2 benchtop immunoassay system (Photo courtesy of Beckman Coulter Diagnostics).

Vitamin D Levels Associated with Type 2 Diabetes

The incidence of type 2 diabetes has increased substantially in both high-income and low- and middle-income countries in recent decades. Observational studies have reported that higher plasma 25-hydroxyvitamin D (25[OH]D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. More...
06 Jun 2018
Image: The PATHFAST compact immunoanalyzer used for measuring cardiac troponin (Photo courtesy of Mitsubishi Chemical Europe).

Troponin Assays Evaluated for Acute MI

In hospital laboratories and in point-of-care testing, cardiac troponin measurements are achieved by various assays, including “contemporary,” “sensitive” and “highly-sensitive” assays. More...
05 Jun 2018
Image: The Luminex 200 System is a flexible analyzer based on the principles of flow cytometry (Photo courtesy of Luminex).

Method Developed to Detect AFP and GP73 Simultaneously

Liver cancer is the second leading cause of cancer death in males and the sixth in females worldwide. An estimated 782,500 new liver cancer cases and 745,500 deaths occurred worldwide during 2012. More...
05 Jun 2018
Image: The DELFIA Xpress immunoassay analyzer for prenatal screening (Photo courtesy of PerkinElmer).

Serum Biomarkers Improve Preeclampsia Screening

Preeclampsia (PE), which complicates 2% to 3% of pregnancies, is a major cause of mortality and morbidity for the mother and perinatal death and impairment for the baby. More...
31 May 2018
Image: The LTQ Orbitrap XL hybrid ion trap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

New Acquisition Method Expands MS Range and Sampling Depth

A major challenge for proteomics, particularly in studies using complex samples with high dynamic ranges, is that only a small proportion of peptides in a sample are selected for analysis. More...
31 May 2018
Image: The GastroCHECK Gastrolyzer breath test monitor (Photo courtesy of coVita).

Exhaled Breath Test Diagnosis of Cancer Assessed

In the United Kingdom, upper gastrointestinal symptoms account for at least 3% of consultations in primary care and many patients present with advanced-stage disease and only 38% of cases can be treated with a curative intent. More...
29 May 2018
Image: Compared to OpenMS and industry standard MaxQuant, IonStar lowered the amount of missing data in test results from 17% to 0.1%. White area indicates missing data (Photo courtesy of Professor Jun Qu, PhD).

New Protein Analysis Tool Improves Diagnostic Accuracy

The abundance of proteins in the body that correspond with disease or pharmaceutical reactions can provide physicians with vital clues for accurately diagnosing a condition, and for developing potential therapies and evaluating drug effects. More...
23 May 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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