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Clinical Chemistry

Image: Histopathology: (D) H&E staining showing the trabecular pattern of MAFA mutation-positive insulinomas. (E) Immunostaining shows diffuse MAFA expression in the tumor, at lower levels compared with the neighboring normal islets strongly expressing MAFA (Inset) (Photo courtesy of the Queen Mary University of London).

Mutation Found in Families with Contradictory Blood Sugars

Insulinomatosis is a condition characterized by the occurrence of multicentric insulinomas, pancreatic neuroendocrine tumors with β-cell–like features causing hyperinsulinemic hypoglycemia. More...
01 Feb 2018
Image: The FreeStyle Libre continuous glucose monitoring system (Photo courtesy of Abbott).

New Guidelines Issued for Diabetes Testing

The American Diabetes Association (ADA) in its 2018 Standards of Medical Care in Diabetes is recommending continuous glucose monitoring (CGM) to all adults 18 and over who are not meeting glycemic targets, as well as screening high-risk youths for type 2 diabetes. More...
30 Jan 2018
Image: New accurate cholesterol test may allow patients to pass on fasting (Photo courtesy of Johns Hopkins School of Medicine).

New Cholesterol Calculation May Avoid Fasting

In a direct comparison study, scientists have added to evidence that a newer method of calculating low-density lipoprotein-cholesterol levels in the blood is more accurate than the older method in people who did not fast before blood was drawn. More...
23 Jan 2018
Image: A digitally colorized scanning electron microscopic (SEM) photograph depicting a single, red-colored H9-T-cell that had been infected by numerous, spheroid-shaped, mustard-colored human immunodeficiency virus (HIV) particles, which can be seen attached to the cell\'s surface membrane (Photo courtesy of the US National Institute of Allergy and Infectious Diseases).

Serum Albumin Level Predicts Serious HIV Events

Serum albumin may be used to stratify human immunodeficiency virus (HIV)–infected persons with a high CD4+ T-cell count according to their risk of serious non-Acquired Immune Deficiency Syndrome (AIDS) endpoints. More...
18 Jan 2018
Image: The RAPIDPoint 500 analyzer (Photo courtesy of Siemens Healthineers).

Blood Gas Analyzers for POC Validated

Several aspects of pH and blood gas analysis are unique in laboratory analysis, and furthermore, no other test results have such a great and immediate impact on patient care. In addition, it is now possible to carry out further vital biological assays on the same sample. More...
15 Jan 2018
Image: The ACQUITY UPLC I-Class / Xevo TQ-S IVD system (Photo courtesy of Waters).

Lipidome Tested As Predictor in T2DM Progression

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by hyperglycemia, which results from impaired insulin secretion of pancreatic β-cells and from ineffective cellular response to insulin. More...
11 Jan 2018
Image: The skin-like biosensor system developed for noninvasive blood glucose monitoring (Photo courtesy of Tsinghua University).

Biosensor System Developed for Blood Glucose Monitoring

Currently, noninvasive glucose monitoring is not widely appreciated because of its uncertain measurement, accuracy, weak blood glucose correlation and inability to detect hyperglycemia/hypoglycemia during sleep. More...
11 Jan 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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