We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Micronutrient Deficiencies Common in Celiac Disease

By LabMedica International staff writers
Posted on 09 Jul 2019
Celiac disease is an immune reaction to consuming gluten, a protein found in wheat, barley and rye. More...
Eating gluten triggers an immune response in the small intestine that over time damages the intestine's lining and prevents it from absorbing some nutrients, leading to diarrhea, fatigue, anemia, weight loss and other complications.

Recent guidelines on the diagnosis and management of Celiac disease (CD) recommend testing for nutrient deficiencies at the time of new diagnosis, and this assessment should include vitamin D, iron, folic acid, and vitamin B12. Micronutrient deficiencies, including vitamins B12 and D, as well as folate, iron, zinc and copper, are common in adults at the time of diagnosis with celiac disease.

Gastroenterologists at the Mayo Clinic (Rochester, MN, USA) and their colleagues carried out a retrospective analysis of 309 adult patients with a new diagnosis of CD from January 1, 2000, and October 31, 2014. Patients included in this study were diagnosed with CD, with a combination of serological, genetic, and histological parameters yielding a confident diagnosis of CD when patients met one of two clinical scenarios. First, if the patient had positive serology for celiac disease and confirmatory duodenal biopsy, CD was diagnosed. Second, patients without positive serology for celiac disease must have biopsy findings consistent with CD, human leukocyte antigen DQ-2 or DQ-8, and positive response to a gluten-free diet for a diagnosis of CD.

Laboratory parameters were included if they were collected one month before diagnosis to three months after celiac diagnosis. Tissue transglutaminase IgA data were collected to determine whether a positive result was associated with deficiency. Micronutrient data were collected for serum zinc, 25-hydroxy vitamin D, ferritin, albumin, serum copper, serum folate, and vitamin B12. Albumin was assessed, as this can influence serum zinc values and is a predictor of outcome in refractory CD studies.

The investigators found that zinc was deficient in 59.4% (126/212) of patients with CD compared with 33.2% (205/618) of controls. Albumin was low in 19.7% (24/122) compared with 1.1% of controls. Copper was low in 6.4% (13/204) compared with 2.1% (13/618) of controls. Vitamin B12 was low in 5.3% (13/244) compared with 1.8% (11/618) of controls. Folate was low in 3.6% (6/159) compared with 0.3% (2/618) of controls. 25-Hydroxy vitamin D was low in 19.0% (44/213) compared with 18% (111/618) of controls. Ferritin was low in 30.8% (66/214) of patients.

Adam Bledsoe, MD, a gastroenterologist and lead author of the study, said, “Our study suggests that the presentation of celiac disease has changed from the classic weight loss, anemia and diarrhea, with increasing numbers of patients diagnosed with non-classical symptoms. Micronutrient deficiencies remain common in adults, however, and should be assessed.”

The authors concluded that micronutrient deficiencies remain common in adults with recently diagnosed CD despite the low prevalence of weight loss and average overweight BMI. These data, in conjunction with previous descriptions of micronutrient deficiencies, suggest value in continued micronutrient assessment of adults at the time of CD diagnosis. The study was published on June 25, 2019, in the journal Mayo Clinic Proceedings.

Related Links:
Mayo Clinic


Gold Member
Quantitative POC Immunoassay Analyzer
EASY READER+
Serological Pipet Controller
PIPETBOY GENIUS
New
Silver Member
Quality Control Material
NATtrol Chlamydia trachomatis Positive Control
New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: The RNA-seq based diagnostic test for pediatric leukemia ensures better outcomes for children with this common cancer (Photo courtesy of Qlucore)

RNA-Seq Based Diagnostic Test Enhances Diagnostic Accuracy of Pediatric Leukemia

A new unique test is set to reshape the way Acute Lymphoblastic Leukemia (BCP-ALL) samples can be analyzed. Qlucore (Lund, Sweden) has launched the first CE-marked RNA-seq based diagnostic test for pediatric... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.