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Clinical Chemistry

Image: The TripleTOF 6600 Quadrupole Time-Of-Flight (QTOF) mass analyzer (Photo courtesy of Sciex).

Protein Panel Developed for Early Detection of Lung Cancer

Lung cancer is the most common cause of cancer-related mortality worldwide, characterized by late clinical presentation as 49%–53% of patients are diagnosed at stage IV, and consequently have poor outcomes. More...
18 Sep 2019
Image: Islet of Langerhans from the pancreas of a patient with chronic Type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Biomarker Identified for Early Beta-Cell Death in Type 1 Diabetes

Beta cells in the pancreas produce insulin and their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. More...
18 Sep 2019
DIASOURCE (A Biovendor Company)
Image: The High Mobility Group Box protein 1 (HMGB1) quantitative enzyme-linked immunosorbent assay kit (Photo courtesy of Shino-Test Corporation).

Serum HMGB1 Levels Reflect Clinical Features of HLH

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. Hypercytokinemia secreted from dysregulated hyperactivated monocytes, macrophages, T cells and NK cells has been reported to play a major role in HLH. More...
17 Sep 2019

Increased Risk of Hypoandrogenemia Found in Obese Young Men

Hyperandrogenism is a medical condition characterized by high levels of androgens in females, but men with obesity may be at increased risk for developing hypoandrogenemia or low free testosterone, especially if they have more severe obesity. More...
12 Sep 2019
Image: The i-STAT Alinity system integrates with-patient testing directly into the patient-care pathway, accelerating time to treatment, improving quality and increasing access to care (Photo courtesy of Abbott).

New Blood Test Helps Detect Brain Injury in Minutes

After traumatic brain injury (TBI), plasma concentration of glial fibrillary acidic protein (GFAP) correlates with intracranial injury visible on computerized axial tomography (CT) scan. Some patients with suspected TBI with normal CT findings show pathology on magnetic resonance imaging (MRI). More...
11 Sep 2019

Gout Increases Risk of Advanced Chronic Kidney Disease

Chronic kidney disease (CKD) is a major public health epidemic, with at least 1 in 10 individuals having some degree of kidney impairment, contributing substantially to adverse clinical and economic outcomes. More...
11 Sep 2019
Image: A major new study on the association between blood glucose levels, including HbA1c, and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care (Photo courtesy of HealthEngine).

Blood Sugar Levels Affect Risks in Type 1 Diabetes

Type 1 diabetes is the predominant form of diabetes diagnosed in childhood and is characterized by increased blood glucose levels resulting from insulin deficiency. More...
11 Sep 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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