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Clinical Chemistry

Image: In the brain of mice with Alzheimer\'s, areas near amyloid plaques (A) appear with fewer neural networks (B), dying neurons (C) and higher OCIAD1 (D). In cultured neuronal cells, the OCIAD1 proteins (E) appear in the mitochondria (F) (Photo courtesy of Houston Methodist Research Institute).

Ovarian Cancer Protein Contributes to Alzheimer`s Disease Neurodegeneration

 Alzheimer's disease is a complex neurological disorder with pathological hallmarks of hyperamyloidosis (senile plaques), neurofibrillary tangles containing hyperphosphorylated tau, and extensive neurodegeneration in the brain. More...
30 Jan 2020
Image: The Sebia Hydragel 18 Apo E Isofocusing showing different apoE isoforms from 16 patients tested. The “control serum” provided in the Sebia kit is included in each series, together with two already typed serum samples as internal controls (as an example, E3/E2 and E4/E4) (Photo courtesy of Sorbonne University).

Semi-Automatic Isoelectric Focusing Evaluated for Apolipoprotein E Phenotyping

 Plasma apolipoprotein E (apoE) mainly arises from liver hepatocytes (75%), but the brain (astrocytes, oligodendrocytes, microglia, astrocytes) also synthesizes apoE found in the cerebrospinal fluid. More...
30 Jan 2020
Image: The Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Urinary Method Detects Toxin Exposure from Harmful Algal Blooms

 During harmful algal blooms (HABs), species of cyanobacteria release toxic peptides, including microcystins and nodularin into waterways, impacting wildlife and humans living in these marine environments. More...
29 Jan 2020
Image: Schematic diagram of deep vein thrombosis (DVT) that is associated with metabolic syndrome (Photo courtesy of MediConnect).

Metabolic Syndrome Associated with Increased Blood Clot Recurrence Risk

 People with metabolic syndrome which are a set of conditions including obesity, impaired glucose metabolism, elevated levels of fats and cholesterol in the blood, and high blood pressure, are more likely to experience recurrent blood clots. More...
21 Jan 2020
Image: Histopathology of Leptomeningeal Melanoma Metastases: tumor cell clusters in the subarachnoid space in a brain biopsy (Photo courtesy of selbst).

Molecular Characteristics of Leptomeningeal Melanoma Metastases Identified

 Patients with advanced melanoma who develop metastases in the leptomeninges, the fluid filled membranes surrounding the brain and spinal cord, have an extremely poor prognosis. Most patients only survive for eight to 10 weeks after diagnosis. More...
20 Jan 2020
Image: Synergy H1 Hybrid Multi-Mode Reader is a configurable microplate reader (Photo courtesy of BioTek)

Higher Female TSH Associated With Lower Mannan-Binding Lectin

 Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Lower MBL levels are associated with, among other conditions, hypothyroidism and adverse pregnancy outcomes. More...
15 Jan 2020
Image: Immunoassay for the in vitro quantitative determination of NT-proBNP in heparinized venous blood for use with the cobas h 232 instrument (Photo courtesy of Axonlab)

Cardiac Blood Test Predicts Post-Surgical Outcomes

 Globally, of the 200 million adults who undergo major surgery, 18% will experience serious cardiac and vascular complications including death within 30 days following their intervention, such as hip and knee replacements, bowel resections and abdominal aortic aneurysm repair. More...
08 Jan 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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