We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Gout Increases Risk of Advanced Chronic Kidney Disease

By Labmedica International staff writers
Posted on 11 Sep 2019
Print article
Image: A new study suggests patients with gout are at elevated risk for chronic kidney disease (Photo courtesy of Shutterstock).
Image: A new study suggests patients with gout are at elevated risk for chronic kidney disease (Photo courtesy of Shutterstock).
Chronic kidney disease (CKD) is a major public health epidemic, with at least 1 in 10 individuals having some degree of kidney impairment, contributing substantially to adverse clinical and economic outcomes.

Gout is the most common inflammatory arthritis, which causes severe pain and suffering due to a build-up of uric acid in joints. It affects almost 2.5 % of the adult population and causes significant pain and disability due to its effects on joints, tendons and bone.

A team of scientists working with the University of Limerick (Limerick, Ireland) analyzed the risk of advanced chronic kidney disease (CKD) in 68,897 gout patients followed for an average of 3.7 years and compared them to 554,964 patients without gout. The primary and secondary outcome measures: Advanced CKD was defined as first occurrence of: (1) dialysis, kidney transplant, diagnosis of end-stage kidney disease (ESKD) or stage 5 CKD; (2) estimated glomerular filtration rate (eGFR) <10 mL/min/1.73 m²; (3) doubling of serum creatinine from baseline and (4) death associated with CKD.

The team reported that advanced CKD incidence was higher for patients with gout (8.54 per 1000 patient-years) versus without gout (4.08). Gout was associated with higher advanced CKD risk in both unadjusted analysis (Hazard ratio [HR], 2.00) and after adjustment (HR, 1.29). Association was strongest for ESKD (HR, 2.13) and was present for eGFR <10 mL/min/1.73 m² (HR, 1.45) and serum creatinine doubling (HR, 1.13), but not CKD-associated death (HR, 1.14) Association of gout with advanced CKD was replicated in propensity-score matched analysis (HR, 1.23) and analysis limited to patients with incident gout (HR, 1.28).

Austin G. Stack, MBBCh, MD, MSc, FASN, FRCPI, a Professor of Medicine and the lead author of the study, said, “We discovered that patients who suffered from gout had a 29% higher risk of advanced CKD compared to those without gout. Indeed when we analyzed each of the components of advanced kidney disease, we found that in general gout patients were at higher risk of deterioration in kidney function compared to those without. Astonishingly, when we looked at the risk of kidney failure and those who needed dialysis or a kidney transplant, we found that gouts patients had more than a 200% higher risk of kidney failure than those without gout.” The study was published on August 28, 2019, in the journal BMJ Open.

Related Links:
University of Limerick

Print article


Molecular Diagnostics

view channel
Image: Illustration depicting the effects of high blood pressure (Photo courtesy of Wikimedia Commons)

Blood Biomarkers Identify Individuals at Risk of Heart Attack or Stroke

A recent study found that elevated levels of high-sensitivity cardiac troponin T or NT-proBNP characterized individuals with elevated blood pressure (BP) or hypertension not currently recommended for ... Read more


view channel
Image: A blood film showing neutrophils and lymphocytes and other white and red blood cells, and a platelet (Photo courtesy of University of Minnesota).

Hematological Ratios Associated with Mortality in Pediatric Trauma Patients

Trauma-related injury as a potential cause of death affects millions of people worldwide, especially in less developed countries and furthermore, it is the leading cause of mortality in pediatric trauma patients.... Read more
Copyright © 2000-2019 Globetech Media. All rights reserved.