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Clinical Chemistry

Image: The single gene, Cystic Fibrosis Transmembrane Regulator (CFTR) gene is located on the long arm of chromosome 7, and its mutations cause CF (Photo courtesy of Daryl Isaac).

Biomarkers Evaluated for Lung Disease Severity in Cystic Fibrosis

Cystic fibrosis (CF) is one of the most common life-shortening monogenic disorders amongst European-derived populations currently affecting more than 85,000 patients worldwide. The diagnosis of CF is based on consensus clinical and laboratory criteria. More...
22 Jun 2020
Image: A Thermo Fisher Orbitrap ID-X mass spectrometer used to analyze blood plasma metabolites in ALS patients (Photo courtesy of North Carolina State University).

Metabolite Profiling Reveals Predictive Biomarkers for Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is characterized by stiff muscles, muscle twitching, and gradually worsening weakness due to muscles decreasing in size. It may begin with weakness in the arms or legs, or with difficulty speaking or swallowing. More...
11 Jun 2020
DIASOURCE (A Biovendor Company)
Image: The Varioskan LUX multimode microplate reader (Photo courtesy of Thermo Fisher).

Serum Free Thiols Predict Cardiovascular Events

Cardiovascular disease (CVD) is among the leading causes of morbidity and mortality globally, and during the past decade, the number of CVD-associated deaths has increased by 12.5%. Free thiols associate with favorable disease outcomes in many patient cohorts, and the current hypothesis is that oxidative stress might also play an important role in cardiovascular disease. More...
08 Jun 2020
Image: FlexStation 3 Microplate Reader measures absorbance, fluorescence intensity, fluorescence polarization, luminescence, and time-resolved fluorescence (Photo courtesy of Molecular Devices).

Urine Testing Method Developed for Ureterolithiasis

Ureterolithiasis (nephrolithiasis or kidney stones) is a disease affecting the urinary tract. Kidney stones occur due to buildup of certain salts and minerals that form crystals, which in turn stick together and enlarge to form a hard mass in the kidneys. The stones move into the urinary tract and can cause blood in the urine, considerable pain and blockages in the urinary system. More...
03 Jun 2020
Image: A pre-conception elevated glycated hemoglobin (HbA1c) is associated with a higher risk of severe maternal morbidity or death among women without known diabetes, and below thresholds commonly used to diagnose diabetes mellitus (Photo courtesy of Diabetes.co.uk).

Glucose Levels Linked to Maternal Mortality Even in Non-Diabetic Women

The prevalence of diabetes mellitus (DM) and obesity have rapidly increased worldwide. Serum glycated hemoglobin A1c (HbA1c), expressed as an absolute percent (e.g., 5.5%), offers a convenient and representative measure of average blood glucose control among individuals with DM. More...
02 Jun 2020
Image: The QSight Triple Quad 400 Series Liquid Chromatography Mass Spectrometry (Photo courtesy of PerkinElmer).

Endogenous Testosterone Levels Associated with Risk of Diabetes

High plasma levels of endogenous total and circulating free testosterone are associated with a two- to sevenfold increased risk for developing type 2 diabetes among young, healthy women without comorbidities. More...
02 Jun 2020
Image: The C-reactive protein (CRP) test was one of the biomarkers evaluated in children with community-acquired pneumonia (Photo courtesy of Healsens Digital Preventive Care).

Biomarkers Evaluated in Children with Community-Acquired Pneumonia

Community acquired pneumonia (CAP) is one of the most common conditions treated by pediatricians, yet predicting disease severity and prognosis is often difficult at the initial presentation. More...
01 Jun 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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