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Clinical Chemistry

The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample. While the ELISA test is sensitive, patients can have high levels of cTnI in the blood without having heart disease, which can lead to expensive and unnecessary treatments for patients. More...
20 Aug 2020
By measuring glycated hemoglobin (HbA1c), clinicians are able to get an overall picture of what the average blood sugar levels have been over a period of weeks/months (Photo courtesy of Diabetes.co.uk).

High Blood Glucose Tied to Cardiovascular Risk in Diabetes

 Glycated hemoglobin (HbA1c) is a measure of an overall picture of what the average blood sugar levels have been over a period of weeks/months. If the blood sugar levels have been high over recent weeks, the hemoglobinA1c test will be higher. More...
14 Aug 2020
Typical GC-IMS output of a vaginal swab. Red spots indicate individual chemicals and machine learning identifies which of these chemicals hold discriminatory information (Photo courtesy of the University of Warwick).

New Technique Predicts Preterm Births in High Risk Women

Globally, preterm birth is the leading cause of death in children under 5 years with 15 million babies being born before 37 weeks’ gestation each year. Spontaneous preterm birth is a syndrome, which can be precipitated by a variety of factors. More...
14 Aug 2020
The AB MDS SCIEX API4000 tandem mass spectrometer (Photo courtesy of SCIEX).

Dolichol Biomarker Evaluated for Congenital Disorders of Glycosylation

A congenital disorder of glycosylation (CDG; previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. More...
14 Aug 2020
Image: The Xevo mass spectrometer with an Acquity ultra high performance chromatography system (Photo courtesy of Waters Corporation).

Simple Urine Test Significantly Improves Detection of Adrenal Cancer

Prognosis for patients discovered to have an adrenal cortical carcinoma (ACC), a cancerous adrenal mass, is poor, and a cure is only achievable through early detection and surgery. The incidental discovery of an adrenal mass often triggers additional scans to determine whether the mass is cancerous. More...
06 Aug 2020
Image: The Quantikine ELISA Human Lipocalin-2/NGAL Kit is a solid phase sandwich ELISA that quantifies human Lipocalin-2/NGAL in serum, heparin plasma, saliva, and urine (Photo courtesy of R&D Systems).

Lipocalin 2 Proposed as Biomarker for Bacterial Meningitis

Central nervous system (CNS) infections cause significant mortality and morbidity worldwide. Common CNS infections include bacterial meningitis (BM) other than tuberculosis, viral encephalitis, tuberculous meningitis (TBM) and cryptococcal meningitis, but there are more than 100 documented infectious causes of CNS infections. More...
05 Aug 2020
Image: A kit for measuring beta-hydroxybutyrate as a biomarker for diabetic ketoacidosis (Photo courtesy of BioSystems).

Protracted Ketonemia Reported in Hyperglycemic COVID-19 Emergencies

Diabetes is a major contributor to disease severity and mortality in patients with COVID-19; with an estimated 3.5-times increase in risk of death during hospital admission for patients with type 1 diabetes, and 2.03-times for those with type 2 diabetes. More...
03 Aug 2020
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Ketosis and DKA Test
D-3-Hydroxybutyrate (Ranbut) Assay
Portable Electronic Pipette
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Rapid Molecular Testing Device
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Gram-Negative Blood Culture Assay
LIAISON PLEX Gram-Negative Blood Culture Assay


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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