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Clinical Chemistry

Image: The LecChip and GlycoStation were used to identify subtle surface ABO blood group glycoprotein density variations (Photo courtesy of Glycotechnica).

Complex ABO Glycan Phenotypes Predicted by Lectin Microarrays

Serological classification of individuals as A, B, O, or AB is a mainstay of blood banking. ABO blood groups or ABH antigens, in addition to other surface glycans, act as unique red blood cell (RBC) signatures and direct immune responses. ABO subgroups present as weakened, mixed field, or unexpected reactivity with serological reagents, but specific designations remain complex. More...
16 Sep 2020
Image: Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer (Photo courtesy of Thermo Fisher Scientific).

Novel Blood Test Predicts Psychotic Disorders Before They Emerge

Only around a quarter of young people who display mild, transitory psychotic symptoms at an early age ultimately go on to develop a serious psychotic disorder. Schizophrenia, for example, is generally not clinically diagnosed until a person reaches their twenties. More...
15 Sep 2020
Image: Impact of maternal HbA1c levels ≤ 6% and race in non-diabetic pregnancies on birth weight and early neonatal hypoglycemia (Photo courtesy of Diabetes Self-Management).

Equivocal HbA1c Test Results Increases Risk of Neonatal Hypoglycemia

Maternal diabetes, including gestational diabetes, typically diagnosed by an oral glucose tolerance test in the second trimester, is a known risk factor for neonatal hypoglycemia and infants born large for gestational age. More...
10 Sep 2020
Image: The Bio-Plex Luminex 200 instrument is a suspension array system which offers protein and nucleic acid scientists a reliable multiplex assay solution that permits analysis of up to 100 biomolecules in a single sample (Photo courtesy of Bio-Rad Laboratories).

Diabetes Blood Markers Linked to Alzheimer’s Disease Pathology

Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. In its early stages, memory loss is mild, but late-stage Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment. More...
09 Sep 2020
Image: The UltiMate 3000 RS HPLC system and mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Plasma Eicosanoids Characterized During Gestation Predicts Outcome

Fetal growth disorders are major risk factors for adverse pregnancy and later life outcomes. Proxy outcomes for disorders of fetal growth include small for gestational age (SGA) and large for gestational age (LGA) birth weight. Risk factors for SGA include maternal obstetrical complications, fetal genetic factors, infection, and various medical conditions. More...
03 Sep 2020
Image: A blood film with a normal mature lymphocyte with a single large nucleus is seen on the left, compared to two segmented neutrophils on the right with multiple nuclear lobes. The lymphocytes are decreased in comorbid diabetes and COVID-19 patients (Photo courtesy of Ed Reschke).

Lymphocyte Count Correlated to Comorbid Diabetes and COVID-19

The coronavirus disease (COVID-19) that erupted in China since December 2019 and has gradually spread throughout the world. At present, it has caused tens of thousands of deaths, and the efficacy of certain antiviral drugs is still under review. More...
03 Sep 2020
Image: iCHROMA is an automatic or semiautomatic in-vitro diagnostic device that measures via cartridges the concentration of analytes, contained in blood, urine, or other samples, in quantitative or semi-quantitative ways (Photo courtesy of Boditech Med Inc).

Biomarkers Evaluated for Severity of Diabetic Kidney Disease

Type 2 diabetic mellitus (T2DM) is a chronic metabolic disorder with multiple complications, including diabetic retinopathy, diabetic neuropathy, diabetic kidney disease (DKD) as well as cardiovascular diseases. T2DM is related to an exacerbated systematic inflammation. More...
24 Aug 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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