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Clinical Chemistry

Image: Immulite 2000 XPi immunoanalyzer system (Photo courtesy of Siemens Healthcare Diagnostics)

Maternal Free Thyroxine Associated with Gestational Diabetes

Hyperglycemia resulting from glucose intolerance during pregnancy, known as gestational diabetes mellitus (GDM), is a common complication during pregnancy and has a major impact on public health worldwide. More...
06 May 2021
Image: The FUS-2000 automated urine analyzer (Photo courtesy of DIRUI)

ANGPTL8 Levels Associated with Hyperlipidemia in Primary Nephrotic Syndrome

The typical clinical manifestations of Primary Nephrotic Syndrome (PNS) include massive proteinuria, hypoproteinemia, edema and/or hyperlipidemia. Of these, marked proteinuria is the core clinical manifestation, and its severity often parallels the degree of hyperlipidemia. More...
28 Apr 2021
Image: Altered Perivascular Fibroblast Activity Precedes Amyotrophic Lateral Sclerosis Onset (Photo courtesy of Karolinska Institutet)

Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. The cause of ALS is only understood in the 5% to 10% of patients who have an inherited form of the disease. More...
28 Apr 2021
Image: The Simoa HD-1 Analyzer (Photo courtesy of Quanterix)

Blood-Based Markers Tied to Brain Cell and Memory Loss

Previous studies have linked elevated levels of plasma total tau and neurofilament light chain (NfL) with worse cognition and neuroimaging measures of cortical thickness, cortical atrophy, white matter hyperintensity, or white matter integrity. More...
27 Apr 2021
Image: The cobas c 701 module is a high throughput clinical chemistry module that performs photometric assay tests for a wide range of analytes (Photo courtesy of Roche Diagnostics)

Serum α-L-Fucosidase Activity Measured for COVID-19 Infection

An unusual fucosylated LacdiNAc in the receptor-binding domains of the spike protein of COVID-19 has been observed. Reduced fucosylation was also found in a specific Fc domain of IgG antibodies in COVID-19 patients that enhanced the interactions with the activating FcγR, FcγRIIIa. More...
22 Apr 2021
Image: The Rayto RT‐6500 microplate reader (Photo courtesy of Rayto Life and Analytical Sciences)

Urinary Heat Shock Protein 70 Evaluated in Chronic Prostatitis

Chronic prostatitis (CP) is a common, but a confusing urological disease that seriously affects men's lives and health and cannot be ignored. The incidence rate is increasing, and the disease is affecting younger men and long‐term prostatitis affects male sexual function. More...
21 Apr 2021
Image: The BreathID Exalenz device (Photo courtesy of Meridian Bioscience)

Breath Test Determines Severity of Methylmalonic Acidemia Disease

Methylmalonic acidemia is a disorder in which the body cannot break down certain proteins and fats. The result is a buildup of a substance called methylmalonic acid in the blood. This condition is passed down through families and is one of several conditions called an "inborn error of metabolism." More...
20 Apr 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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