We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Randox Laboratories

  Platinum Provides global diagnostic solutions for hospital laboratories, forensic laboratories, research laboratories, pharmac... read more Featured Products: More products

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Elevated Lipoprotein(a) Mediates Risk of Atrial Fibrillation

By LabMedica International staff writers
Posted on 27 Apr 2022
Print article
Image: The Randox Lipoprotein(a), (Lp(a)), assay offers a truly accurate method for the assessment of Lp(a) in serum or plasma (Photo courtesy of Randox Laboratories)
Image: The Randox Lipoprotein(a), (Lp(a)), assay offers a truly accurate method for the assessment of Lp(a) in serum or plasma (Photo courtesy of Randox Laboratories)

Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults, with a prevalence between 0.5% and 2%. Longer life span and higher prevalence of AF risk factors are projected to further increase the global prevalence of AF.

Patients with AF have greater risks of heart failure, ischemic stroke, dementia, and death, and are more likely to be hospitalized, resulting in higher health care costs. Lipoprotein(a) (Lp[a]) is a particle consisting of a low-density lipoprotein (LDL)-like core attached to an apolipoprotein(a) chain. Lp(a) plays a role in atherosclerotic cardiovascular disease and is a well-established risk factor for coronary artery disease, ischemic stroke, and aortic valve stenosis.

Medical Scientists at McMaster University (Hamilton, ON, Canada) and their colleagues investigated the role of Lp(a) in AF and whether it is independent of atherosclerotic cardiovascular disease (ASCVD). The team measured and genetically predicted Lp(a) levels were tested for association with 20,432 cases of incident AF in the UK Biobank (N = 435,579). Mendelian randomization analyses were performed by using summary-level data for AF from publicly available genome-wide association studies (N = 1,145,375). Lp(a) was measured on a Randox AU5800 immunoturbidimetric assay (Randox Laboratories, Crumlin, UK) that used a 5-point calibrator to reflect heterogeneity in Lp(a) isoform size.

The investigators reported that after a median 11 years of follow-up, the rate of incident AF was 4.37 events per 1,000 person-years. They found that each 23 mg/dL increase in Lp(a) was associated with a 3% increased risk for incident AF using measured Lp(a) (HR = 1.03) and genetically predicted Lp(a), with an OR of 1.03. Mendelian randomization analyses using independent data replicated the effect, with an OR of 1.04 per 23 mg/dL increase. They found no evidence of risk-conferring effect from LDL or triglycerides, whereas only 39% of Lp(a) risk was mediated through ASCVD, suggesting Lp(a) partly influences AF independent of its known effects on ASCVD.

Guillaume Pare, MD, MSc, FRCPC, a professor of pathology and molecular medicine and senior author of the study, said, “Lipoprotein(a) is associated with an increased risk for atrial fibrillation and this appears to be a causal relationship independent of coronary artery disease and aortic valve stenosis. The main clinical implication is the exciting possibility that novel Lp(a) inhibitors, currently undergoing clinical evaluation, could reduce incident AF as a side benefit. Our findings also establish a new risk factor for AF and could be used to complement AF risk assessment.”

The authors concluded that epidemiologic and genetic analyses implicate a potentially causal role for Lp(a) on risk of incident AF in population-scale cohorts that is independent of its effect on atherosclerotic cardiovascular disease. Given the role of Lp(a) as a risk factor for common comorbidities of AF, namely stroke and myocardial infarction, and the development of antisense oligonucleotides to lower Lp(a) to treat these comorbidities, these findings highlight an important beneficial pleiotropic effect these therapies may have on prevention or treatment of AF in high-risk groups with highly elevated Lp(a). The study was published in the April, 2022 issue of the Journal of the American College of Cardiology.

Related Links:
McMaster University 
Randox Laboratories 

Gold Supplier
Pipette Tips
Sapphire Pipette Tips
Silver Supplier
3-Part Hematology Analyzer
Silver Supplier
Anti-Müllerian Hormone (AMH) ELISA Test
Silver Supplier
Receptor Destroying Enzyme
RDE II (Receptor Destroying Enzyme)

Print article


Molecular Diagnostics

view channel
Image: This image depicts a DNA molecule that is methylated on both strands on the center cytosine. DNA methylation plays an important role for epigenetic gene regulation in development and cancer (Photo courtesy of Wikimedia Commons)

Study Supports Use of Methylated DNA Biomarkers for Cancer Diagnosis and Prognosis

A recent study added weight to the theory that methylated DNA biomarkers could be used for cancer diagnosis and prognosis. Methylation is a biological process by which methyl groups are added to a DNA molecule.... Read more


view channel
Image: Standard test for multiple myeloma provides clues of a rare, more deadly type (Photo courtesy of Pexels)

Standard Blood Cancer Test Provides Clues of Rare IgD Multiple Myeloma

IgD myeloma accounts for about 1% of common blood cancer multiple myeloma and has a worse prognosis. Specific testing for IgD myeloma is available at a handful of reference labs across the US, but takes... Read more


view channel
Image: QIAGEN has acquired a majority stake in enzymes provider BLIRT S.A. (Photo courtesy of QIAGEN)

Qiagen Acquires Enzymes Provider Blirt to Strengthen Sample Technologies Business

QIAGEN N.V. (Venlo, Netherlands) has signed agreements to acquire a 96% majority ownership stake in BLIRT S.A. (Gdansk, Poland), a manufacturer of recombinant enzymes for the life science industry.... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.