We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBE SCIENTIFIC, LLC

Randox Laboratories

Provides global diagnostic solutions for hospital laboratories, forensic laboratories, research laboratories, pharmac... read more Featured Products: More products

Download Mobile App




Elevated Lipoprotein(a) Mediates Risk of Atrial Fibrillation

By LabMedica International staff writers
Posted on 27 Apr 2022

Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults, with a prevalence between 0. More...

5% and 2%. Longer life span and higher prevalence of AF risk factors are projected to further increase the global prevalence of AF.

Patients with AF have greater risks of heart failure, ischemic stroke, dementia, and death, and are more likely to be hospitalized, resulting in higher health care costs. Lipoprotein(a) (Lp[a]) is a particle consisting of a low-density lipoprotein (LDL)-like core attached to an apolipoprotein(a) chain. Lp(a) plays a role in atherosclerotic cardiovascular disease and is a well-established risk factor for coronary artery disease, ischemic stroke, and aortic valve stenosis.

Medical Scientists at McMaster University (Hamilton, ON, Canada) and their colleagues investigated the role of Lp(a) in AF and whether it is independent of atherosclerotic cardiovascular disease (ASCVD). The team measured and genetically predicted Lp(a) levels were tested for association with 20,432 cases of incident AF in the UK Biobank (N = 435,579). Mendelian randomization analyses were performed by using summary-level data for AF from publicly available genome-wide association studies (N = 1,145,375). Lp(a) was measured on a Randox AU5800 immunoturbidimetric assay (Randox Laboratories, Crumlin, UK) that used a 5-point calibrator to reflect heterogeneity in Lp(a) isoform size.

The investigators reported that after a median 11 years of follow-up, the rate of incident AF was 4.37 events per 1,000 person-years. They found that each 23 mg/dL increase in Lp(a) was associated with a 3% increased risk for incident AF using measured Lp(a) (HR = 1.03) and genetically predicted Lp(a), with an OR of 1.03. Mendelian randomization analyses using independent data replicated the effect, with an OR of 1.04 per 23 mg/dL increase. They found no evidence of risk-conferring effect from LDL or triglycerides, whereas only 39% of Lp(a) risk was mediated through ASCVD, suggesting Lp(a) partly influences AF independent of its known effects on ASCVD.

Guillaume Pare, MD, MSc, FRCPC, a professor of pathology and molecular medicine and senior author of the study, said, “Lipoprotein(a) is associated with an increased risk for atrial fibrillation and this appears to be a causal relationship independent of coronary artery disease and aortic valve stenosis. The main clinical implication is the exciting possibility that novel Lp(a) inhibitors, currently undergoing clinical evaluation, could reduce incident AF as a side benefit. Our findings also establish a new risk factor for AF and could be used to complement AF risk assessment.”

The authors concluded that epidemiologic and genetic analyses implicate a potentially causal role for Lp(a) on risk of incident AF in population-scale cohorts that is independent of its effect on atherosclerotic cardiovascular disease. Given the role of Lp(a) as a risk factor for common comorbidities of AF, namely stroke and myocardial infarction, and the development of antisense oligonucleotides to lower Lp(a) to treat these comorbidities, these findings highlight an important beneficial pleiotropic effect these therapies may have on prevention or treatment of AF in high-risk groups with highly elevated Lp(a). The study was published in the April, 2022 issue of the Journal of the American College of Cardiology.

Related Links:
McMaster University 
Randox Laboratories 


Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
Serological Pipet Controller
PIPETBOY GENIUS
New
Silver Member
Fibrinolysis Assay
HemosIL Fibrinolysis Assay Panel
New
Celiac Disease Test
Anti-Gliadin IgG ELISA
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.