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BioResearch

Image: The DNMT3A-DNA complex. The structure reveals that DNMT3A molecules attack two substrate sites adjacent to each other on the same DNA molecule. DNMT3L (green) is a regulatory protein of DNMT3A (Photo courtesy of the Song Laboratory, University of California, Riverside).

Enzyme Structure May Lead to Control of DNA Methylation Process

The recently established molecular structure of the enzyme DNA methyltransferase 3A bound to its DNA substrate is expected to eventually lead to the ability to control DNA methylation content and, by extension, gene expression and cell differentiation. More...
20 Feb 2018
Image: A mouse tumor (grey/white areas) being infiltrated by cDC1 (yellow cells) that exited from blood vessels (blue). Red and green identify other immune cells. Infiltration by cDC1 triggers anti-cancer immune responses; this tumor will eventually be rejected by the mouse\'s immune system (Photo courtesy of Dr. Caetano Reis e Sousa, The Francis Crick Institute).

Tumors Avoid Destruction by Immune System

A molecular and pathway that aids tumors in avoiding destruction by the immune system was found to comprise natural killer cells, conventional type 1 dendritic cells, and prostaglandin E2. More...
19 Feb 2018
Image: An adenovirus without and with a novel protein shield. The adenovirus (left) was camouflaged from the immune system by the protective coat (right) (Photo courtesy of the University of Zurich).

Modified Adenovirus Vector Used for Cancer Gene Therapy

A team of medical virologists has modified the commonly used adenovirus vector to both avoid clearance by the immune system and liver and to specifically target and invade tumor cells. More...
15 Feb 2018
Image: Vials containing samples of \"hairy\" nanoparticles: the right and left vials contain photo-responsive polymer-capped gold nanoparticles prior to and after self-assembly, respectively. The center vial shows dye released from self-assembled gold nanoparticles. The nanoparticles were made with light-sensitive materials that assembled and disassembled themselves when exposed to light of different wavelengths (Photo courtesy of Rob Felt, Georgia Institute of Technology).

Light-Sensitive Nanoparticles Designed for Smart Drug Release

A novel type of "smart" nanoparticles responds to light of specific wavelengths that causes the particles to assemble or disassemble, which enables the dynamic organization of the nanoparticles for in vitro drug release. More...
14 Feb 2018
Image: A three-dimensional-printed chess king shrinking and growing as water temperatures change (Photo courtesy of Daehoon Han, Rutgers University).

3D Hydrogel Structures Developed for Biomedical Use

A team of biomedical engineers developed a three-dimensional printing method for stimuli-responsive hydrogels that may enable many new applications in diverse areas, including flexible sensors and actuators, bio-medical devices, and tissue engineering. More...
13 Feb 2018
Image: The structure of the OX40 protein (Photo courtesy of Wikimedia Commons).

Immunostimulatory Vaccine Cures Metastatic Cancer in Model

A novel method for treating various types of metastatic cancer based on injection of a pair of immune-stimulating agents directly into solid tumors was demonstrated in a mouse model. More...
12 Feb 2018
Image: The structure of the cancer stem cell-promoting SOX2 protein (Photo courtesy of Wikimedia Commons).

Potential Therapy Blocks Cancer Stem Cell Survival

A suggested new drug regimen for treating bladder cancer targets two enzymes that act to increase the expression of a third enzyme that promotes the survival and growth of a drug resistant population of cancer stem cells. More...
08 Feb 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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