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BioResearch

Image: The long non-coding RNA called A-ROD is only functional the moment it is released from chromatin into the nucleoplasm. At this transient phase, it can bring transcription factors to specific sites in DNA to enhance gene expression. After its complete release from chromatin, A-ROD is no longer active (Photo courtesy of Evgenia Ntini, Max Planck Institute for Molecular Genetics).

Transcription Regulation Depends on Release from Chromatin

A team of German genome researchers has demonstrated that release from chromatin is a crucial functional aspect of long noncoding RNAs in transcription regulation of their target genes. More...
09 May 2018
Image: Histological sections of liver from control mice treated with saline (left) and the CRISPR/Cas9 epigenetic repression system in which cholesterol levels were lowered (right) show generally normal and healthy tissue (Photo courtesy of Dr. Charles Gersbach, Duke University).

Model Demonstrates Potential for Long-Term Gene Silencing

An adeno-associated viral (AAV) vector was used to deliver a modified version of the CRISPR/Cas9 gene-editing tool to liver cells in a mouse model, which resulted in suppression of the serum enzyme Pcsk9 and reduction of cholesterol levels. More...
08 May 2018
Image: Dense FUS protein fibrils form in the absence of nuclear-import receptors (NIRs, left), but are disrupted when NIRs are present (right) (Photo courtesy of Dr. James Shorter, University of Pennsylvania).

Protein Droplets Stimulate Neurodegenerative Fibril Clumping

A team of neurodegenerative disease researchers has identified a molecular mechanism that prevents or reverses the formation of insoluble protein aggregates that characterize several brain disorders, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). More...
03 May 2018
Image: Recovery of the injured heart muscle after four weeks of treatment with extracellular vesicles. Immunostains: wheat germ agglutinin (red), troponin (green), and DAPI [(4\',6-diamidino-2-phenylindole)] (blue) (Photo courtesy of Dr. Gordana Vunjak-Novakovic, Columbia University School of Engineering and Applied Science).

Cardiomyocyte Extracellular Vesicles Repair Heart Damage in Model

Studies conducted with a rat myocardial infarction model demonstrated the benefits of treating damaged heart muscle with extracellular vesicles (EVs) secreted by cardiomyocytes. More...
02 May 2018
Image: An illustration of blood vessels including artery, arteriole, capillaries, vein and venule (Photo courtesy of the [U.S.] National Cancer Institute).

Protein Supports Optimal Vascular System Performance

A protein has been identified that acts as a sensor of mechanical stimulation and is essential for sensing blood flow and supporting optimal performance of the vascular system. More...
01 May 2018
Image: A micrograph of a pancreatic cancer spheroid culture (Photo courtesy of Dr. Shurong Hou, Scripps Research Institute).

HTS Method Based on 3D Tumor Organoid Cultures

A drug development team has described a high-throughput screening (HTS)-compatible method – based on three-dimensional (3D) tumor organoids – for evaluating multiple chemical compounds for potential chemotherapeutic drug candidates. More...
30 Apr 2018
Image: An atomic force microscope inside a FTIR spectrometer with the optical interface (Photo courtesy of Wikimedia Commons).

Ultrasensitive Imaging Enables Characterization of Individual Nanoparticles

An advanced ultrasensitive imaging technique was used to analyze and characterize extracellular vesicles derived from two types of placenta stem cells. More...
26 Apr 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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