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BioResearch

Image: A lymph node with almost complete replacement by metastatic melanoma. The brown pigment is focal deposition of melanin (Photo courtesy of Wikimedia Commons).

Enzyme Pair Identified as Target for Melanoma Chemotherapy

A team of cancer researchers has identified a pair of enzymes that they say could serve as therapeutic targets whose inhibition would block the growth of metastatic melanoma. More...
07 Dec 2017
Image: Researchers developed nanoparticles that can target cancer stem cells (yellow), the rare cells within a tumor (blue) that can cause cancer to recur or spread (Photo courtesy of Dr. Dipanjan Pan, University of Illinois).

Use of Niclosamide to Deactivate Cancer Stem Cells

Nanoparticles designed to selectively deliver the drug niclosamide to cancer stem cells caused the cancer stem cells to lose their stem-like properties and rendered them less able to cause recurrence or metastasis. More...
06 Dec 2017
Image: Breast cancer cells were grown in a highly dense three-dimensional collagen matrix. After seven days the cells formed networks that resembled the early stages of blood vessel development. This photomicrograph shows representative structures observed in these environments after staining for cell nuclei (blue) and cytoskeletons (green) (Photo courtesy of the University of California, San Diego).

Extracellular Collagen Modulates Tumor Progression and Metastasis

A recent paper detailed how factors in the tumor microenvironment induce the cancer to progress and metastasize. More...
05 Dec 2017
Image: Foreground: Drawing of a cardiac muscle. Background: excerpt from a heart map, an overview of the proteins analyzed for the proteomic map (Photo courtesy of Doll, Kraue, Menzfield, Max Planck Institute of Biochemistry).

Heart Map Facilitates Analysis of Cardiac Function

A team of German heart researchers used high-resolution liquid chromatography–mass spectrometry to generate a spatial and cell-type-resolved proteomic map of the healthy human heart that they have made available as a resource tool for future analyses of normal heart function and disease. More...
04 Dec 2017
Image: Investigators have developed nanoparticles that can transport the CRISPR genome-editing system in vivo and specifically modify genes, eliminating the need to use viruses for delivery (Photo courtesy of Massachusetts Institute of Technology).

Nanoparticle-Based System Developed for Delivery of CRISPR/Cas9

A novel nanoparticle transport system was used to deliver the CRISPR/Cas9 genome editing tool into liver cells of living mice, which caused silencing of a specific enzyme and significant lowering of cholesterol levels. More...
30 Nov 2017
Image: CRISPR/Cas9-mediated disruption of genes associated with cuticle pigment caused mosquitoes to turn from black to yellow, and disruption of genes associated with eye pigment caused eye color to change from black to white (Photo courtesy of the University of California, Riverside).

Transgenic Cas9 Mosquitoes Used to Target Disease Carriers

Insertion of the gene encoding the Cas9 enzyme into the germline of Aedes aegypti mosquitos represents a step toward the development of novel population control technologies targeting this carrier of serious viral pathogens including dengue, chikungunya, yellow fever, and Zika. More...
29 Nov 2017
Image: A lysosome ultrastructure (Photo courtesy of Hourlybook Open Source Education Blog).

Researchers Link PD Risk to Lysosomal Gene Mutations

A team of neurodegenerative disease researchers has suggested that multiple genetic defects may act in combination to degrade lysosomal function, which enhances Parkinson’s disease (PD) susceptibility. More...
28 Nov 2017
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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