Tissue Model Used to Show Molecular Basis for Infection

A team of molecular microbiologists has explained the mechanism by which Neisseria gonorrhoeae, the bacterium that causes the urinary tract infection gonorrhea, invades and colonizes female genital tissues.

Since humans are the only host for Neisseria gonorrhoeae (GC), a lack of a human infection model has been a major obstacle to understanding the process of GC infection.

In the current study, investigators at the University of Maryland used a human tissue explant model to examine the mechanism by which GC infect the human endocervix, the primary site for GC infection in women.

They reported in the April 13, 2017, online edition of the journal PLOS Pathogens that GC penetrate into the human endocervix by activating the actin motor myosin protein and epithelial shedding. More...