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Immunology

Image: Histopathology of pediatric non-alcoholic fatty liver disease (NAFLD This trichrome stain illustrates zone 1 steatosis, portal fibrosis, and a ductular reaction, which characterize pediatric NAFLD (Photo courtesy of Elizabeth M. Brunt MD)

Serum Antinuclear Antibody Correlated in Hispanic Pediatric Patients With NFLD

Non-alcoholic fatty liver disease (NAFLD), also known as metabolic (dysfunction) associated fatty liver disease (MAFLD), is excessive fat build-up in the liver without another clear cause such as alcohol use. Obesity and type 2 diabetes are strong risk factors for NAFLD. More...
06 Apr 2022
Image: Livedo Reticularis: this is one of the most important physical signs in Antiphospholipid syndrome (APS) and is felt by many physicians to be an additional risk factor for the risk of APS clinical events, over and above the presence of antiphospholipid antibody (Photo courtesy of Graham Hughes and Shirish Sangle)

Pediatric Antiphospholipid Syndrome Diagnosis Methods Reassessed

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic events and/or pregnancy morbidity in the setting of persistently positive antiphospholipid antibodies (aPL). More...
30 Mar 2022
Image: Photomicrograph of a blood sample specimen, revealed the presence of two flagellated, Trypanosoma cruzi parasites (Photo courtesy of Dr. Mae Melvin/CDC)

Double-Antigen Sandwich ELISA Detects Antibodies to Trypanosoma cruzi

Chagas disease (CD), also known as American trypanosomiasis, is a potentially life-threatening vector-borne tropical zoonosis caused by the protozoan parasite Trypanosoma cruzi. The estimated prevalence of CD in 21 Latin American countries where it is considered endemic exceeds five million individuals; CD accounts for approximately 7,500 deaths annually. More...
29 Mar 2022
Image: Photomicrograph of classic Hodgkin lymphoma (cHL) fine needle aspiration from a lymph node. The micrograph shows a mixture of cells common in cHL: eosinophils, Reed-Sternberg cells, plasma cells, and histocytes (Photo courtesy of Nephron)

Flow Cytometric Immunophenotyping Assessed for Classic Hodgkin Lymphoma

The diagnosis of classic Hodgkin lymphoma (CHL) requires morphologic and immunophenotypic identification of neoplastic Hodgkin and Reed-Sternberg cells (collectively referred to as HRS cells) intermixed with a background of reactive lymphocytes, histiocytes, plasma cells, and eosinophils. More...
24 Mar 2022
Image: The Orbitrap Fusion Mass Spectrometer was used to identify the biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation (Photo courtesy of Thermo Fisher Scientific)

Biomarker Panel for Risk of Early Respiratory Failure Following Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) is a life-saving therapy used for malignant and nonmalignant diseases. However, post-HCT pulmonary complications continue to be a significant problem. When severe, pulmonary complications can result in respiratory failure (RF), affecting 10% to 23% of patients. More...
23 Mar 2022
Image: The NanoSight NS300 utilizes the latest version of NanoSight’s particle characterization technology, Nanoparticle Tracking Analysis (NTA) (Photo courtesy of University of New South Wales)

Serum Extracellular Vesicle Arginase 1 Measured In T2DM

Serum extracellular vesicle (EV)-derived arginase 1 (ARG 1) plays a critical role in diabetes-associated endothelial dysfunction. This study was performed to determine the levels of serum EV-derived ARG 1 in T2DM and non-T2DM participants and to examine the association of serum EV-derived ARG 1 with T2DM incidence. More...
18 Mar 2022
Image: This digitally-colorized, scanning electron microscopic (SEM) photograph depicts a number of corkscrew-shaped, Leptospira sp. bacteria atop a 0.1µm polycarbonate filter (Photo courtesy of Janice Haney Carr/CDC)

Enzyme Immunoassays Developed for Serodiagnosis of Human Leptospirosis

The laborious microscopic agglutination test (MAT) is the gold standard serologic test for laboratory diagnosis of leptospirosis. We developed EIA based serologic assays using recombinant proteins (rLigA, rLigB, rLipL32) and whole-cell extracts from eight Leptospira serovars as antigen and assessed the diagnostic performance of the new assay. More...
14 Mar 2022
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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