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BioResearch

Image: A three-dimensional printed, two-millimeter implant used as scaffolding to repair spinal cord injuries in rats. The circles surrounding the H-shaped core are hollow portals through which implanted neural stem cells can extend axons into host tissues (Photo courtesy of Jacob Koffler and Wei Zhu, University of California, San Diego).

Synthetic Printed Implants Prompt Spinal Regeneration in Model

The potential use of three-dimensional (3D) printing to produce replacement components for the repair of spinal damage was demonstrated in a rat model system. More...
31 Jan 2019
Image: A micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons).

Mouse Biomarker Predicts Lethality of Human Prostate Cancer

Researchers have demonstrated the relevance of a prostate cancer biomarker found in a genetically engineered mouse model to the diagnosis and monitoring of the progress of the disease in humans. More...
30 Jan 2019
Image: Researchers \"knocked out\" the omega-1 ribonuclease protein using CRISPR/Cas9 and found that it greatly reduced the impact of schistosomiasis (Photo courtesy of George Washington University).

Gene Editing Reduces Symptoms of Parasite Infection in Models

Tropical disease researchers used the CRISPR/Cas9 genome-editing tool to interfere with the ability of certain parasitic worms to invade and reproduce in rodent model systems. More...
29 Jan 2019
Image: A scanning electron micrograph (SEM) of engineered T-cells lacking coronin 1 (Photo courtesy of the University of Basel).

Novel Method Prevents Rejection of Transplanted Organs

A team of Swiss researchers reported finding a method that prevents rejection of transplanted organs without lessening the immune system's ability to fight off infection by pathogenic microorganisms. More...
28 Jan 2019
Image: A diagram of how regulatory T-cells suppress effector T-cells and dendritic cells (Photo courtesy of Wikimedia Commons).

Gene Therapy Cures Severe Autoimmune Disorder in Model

An often fatal autoimmune disorder was cured in mice by using a lentiviral vector to insert a working copy of the defective FOXP3 (Forkhead box P3, also known as scurfin) gene into blood stem cells. More...
24 Jan 2019
Image: An example of DNA damage causing multiple broken chromosomes (Photo courtesy of Wikimedia Commons).

Complex DNA Repair Problems Underlie Genome Instability

While low levels of the protein ubiquilin-4 (UBQLN4) are linked to increased sensitivity to genotoxic stress and delayed DNA double-strand break repair, elevated levels of this DNA repair-associated protein have been found in particularly aggressive tumors. More...
23 Jan 2019
Image: ProCas9 can sense the presence of an enzyme called a protease. ProCas9 (left, gray) is inactive until the protease snips a short piece of protein (red loop), at which point it becomes active (right, red) and binds DNA. By making the Cas9 fluoresce when it binds DNA, researchers get a signal that the protease is present (Photo courtesy of University of California, Berkeley).

CRISPR/Cas9 Modified to Increase Its Versatility

A team of molecular biologists has modified the CRISPR/Cas9 gene-editing tool to incorporate an "on switch", which enables the precise manipulation of specific genes in selected cells. More...
22 Jan 2019
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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