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BioResearch

Image: An example of DNA damage causing multiple broken chromosomes (Photo courtesy of Wikimedia Commons).

Complex DNA Repair Problems Underlie Genome Instability

While low levels of the protein ubiquilin-4 (UBQLN4) are linked to increased sensitivity to genotoxic stress and delayed DNA double-strand break repair, elevated levels of this DNA repair-associated protein have been found in particularly aggressive tumors. More...
23 Jan 2019
Image: ProCas9 can sense the presence of an enzyme called a protease. ProCas9 (left, gray) is inactive until the protease snips a short piece of protein (red loop), at which point it becomes active (right, red) and binds DNA. By making the Cas9 fluoresce when it binds DNA, researchers get a signal that the protease is present (Photo courtesy of University of California, Berkeley).

CRISPR/Cas9 Modified to Increase Its Versatility

A team of molecular biologists has modified the CRISPR/Cas9 gene-editing tool to incorporate an "on switch", which enables the precise manipulation of specific genes in selected cells. More...
22 Jan 2019
Image: A representation of the movement of the flower-like particle as it makes its way to deliver therapeutic genes (Photo courtesy of Washington State University).

Fluorinated Nanoparticles Facilitate Drug Transfer to Cellular Cytosol

In a proof-of-principle study, novel "nanoflower" drug transporters were used to successfully deliver model drug analogues to cells growing in culture. More...
22 Jan 2019
Image: Treatment with the drug D-PDMP reduced beta-1,4-GalT-V protein levels in human colorectal cancer cells and killed cancer cells (Photo courtesy of Dr. Subroto B. Chatterjee, Johns Hopkins University).

Blocking Colorectal Cancer Growth by Inhibiting Glycosphingolipid Synthesis

Results of a recent study suggested that inhibition of glycosphingolipid (GSL) synthesis could be a novel approach for the treatment of colorectal cancer. More...
21 Jan 2019
Image: Drug treatment eliminates senescent cells from tissues of old mice. The blue staining shows senescent cells in lung and liver tissue. The amount of the staining is significantly reduced following the drug treatment (Photo courtesy of The Weizmann Institute of Science).

Preventing Accumulation of Senescent Cells Reverses Adverse Signs of Aging

Researchers working with mouse models have shown that some of the less desirable signs of aging, such as chronic inflammation and reduced function of some organs, could be reversed by treatment to reduce the number of senescent cells that have accumulated in the animal. More...
15 Jan 2019
Image: The structure of the ADAR protein (Photo courtesy of Wikimedia Commons).

Inhibition of RNA-Editing Enzyme Sensitizes Tumors to Immunotherapy

An international team of cancer researchers has reported that by blocking the function of the RNA-editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA1) in tumor cells, they could profoundly sensitize tumors to immunotherapy and overcome resistance to checkpoint blockade therapy. More...
14 Jan 2019
Image: Flexible cells: Ordinary cells are not static and predetermined, as was earlier believed. They can change identity and function. This discovery may provide an approach for new types of treatments in the future (Photo courtesy of Dr. Luiza Ghila, University of Bergen).

Neighbor Cell Signals Cause Function Change in Response

A molecular mechanism has been identified that maintains cell identity via an active process, which is mediated by repressive signals released by neighboring cells that curb an intrinsic trend of differentiated cells to change. More...
14 Jan 2019
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.

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