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BioResearch

Image: A micrograph showing tangles of tau protein (green) in the brain cell of a person who had Alzheimer’s disease (Photo courtesy of Thomas Deerinck of the National Center for Microscopy and Imaging Research at the University of Califronia, San Diego School of Medicine).

Lowering Cholesteryl Ester Levels Reduces Tau Tangles

An excess of cholesteryl esters, the storage product for excess cholesterol within cells, was shown to induce tau protein in neurons to form abnormal aggregates called neurofibrillary tangles that are characteristic of Alzheimer's disease. More...
07 Feb 2019
Image: Researchers used CRISPR/Cas9 genome editing to control genetic inheritance in mammals for the first time (Photo courtesy of Cooper Laboratory, University of California, San Diego).

Genome Editing Used to Bias Genetic Inheritance in Mice

Genomics researchers have demonstrated the feasibility of using CRISPR/Cas9 gene editing to bias genetic inheritance in mice used for laboratory studies. More...
06 Feb 2019
Image: Modified human interleukin-27-alpha. Inspired by the murine interleukin-27-alpha, one amino acid has been exchanged, enabling the formation of a disulfide-bridge (marked in red) (Photo courtesy of Dr. M. Feige, Technical University of Munich).

Comparison of Human and Mouse Interleukins Reveals Link

A study comparing the structure and function of human and mouse interleukins revealed a close link between protein folding and immune regulation. More...
05 Feb 2019
Image: A Microscopic examination of brain tissues of prion-infected animals. (Left) Staining shows spongiform degeneration. (Right) Staining shows intense misfolded prion protein (Photo courtesy of Case Western Reserve University).

Sensitive Assays Enable Early Detection of Prion Infection

Researchers working with rodent models have demonstrated the potential for developing a skin test for the early diagnosis of prion diseases in humans. More...
04 Feb 2019
Image: A three-dimensional printed, two-millimeter implant used as scaffolding to repair spinal cord injuries in rats. The circles surrounding the H-shaped core are hollow portals through which implanted neural stem cells can extend axons into host tissues (Photo courtesy of Jacob Koffler and Wei Zhu, University of California, San Diego).

Synthetic Printed Implants Prompt Spinal Regeneration in Model

The potential use of three-dimensional (3D) printing to produce replacement components for the repair of spinal damage was demonstrated in a rat model system. More...
31 Jan 2019
Image: A micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons).

Mouse Biomarker Predicts Lethality of Human Prostate Cancer

Researchers have demonstrated the relevance of a prostate cancer biomarker found in a genetically engineered mouse model to the diagnosis and monitoring of the progress of the disease in humans. More...
30 Jan 2019
Image: Researchers \"knocked out\" the omega-1 ribonuclease protein using CRISPR/Cas9 and found that it greatly reduced the impact of schistosomiasis (Photo courtesy of George Washington University).

Gene Editing Reduces Symptoms of Parasite Infection in Models

Tropical disease researchers used the CRISPR/Cas9 genome-editing tool to interfere with the ability of certain parasitic worms to invade and reproduce in rodent model systems. More...
29 Jan 2019
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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