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Hematology

Image: Micrograph of a diffuse large B cell lymphoma, from a bone marrow aspirate; the nucleus may be convoluted and irregular (Photo courtesy of Peter Maslak)

Molecular Profiles, Microenvironment Signatures May Improve Lymphoma Prognosis

 The tumor microenvironment includes surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix that encapsulate the cancerous cells. The non-lymphoma cells lingering in the tumor's microenvironment, for example, can modify the effect of the mutations. More...
09 Jan 2020
Image: Schematic diagram of how novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation (CBT) (Photo courtesy of MD Anderson Cancer Center).

Immature Natural Killer Cells Predict Relapse After Cord Blood Transplantation

 Umbilical cord blood transplantation (CBT) has become an accepted alternative treatment of patients with hematologic cancers or other disorders. Many of the disadvantages of CBT, including limited numbers of total nucleated cells, have been dealt with in significant ways, leading to marked reductions in the time to hematopoietic cell recovery. More...
31 Dec 2019
Image: The TEG 6s system provides rapid, comprehensive and accurate identification of an individual’s hemostasis condition in a laboratory or point-of-care setting (Photo courtesy of Haemonetics Corporation).

Hypercoagulability Evaluated in New‐Onset Systemic Lupus Erythematosus Patients

 Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that involves T cell, B cell, and dendritic cell dysfunction, as well as antinuclear autoantibody production. Several clinical and scientific studies of SLE indicate an increased risk of thrombosis in these cases. More...
30 Dec 2019
Image: FoundationOne Heme next-generation sequencing test can be used to assess routine cancer specimens for all genes that are currently known to be somatically altered and unambiguous drivers of oncogenesis in hematologic malignancies and sarcomas (Photo courtesy of Foundation Medicine)

Germline Genetic Testing Assesses Inherited Risk for Myeloid Malignancies

 Inherited risk for hematologic malignancies was historically thought to be relatively rare; however, the increased use of next-generation sequencing has identified more patients with germline genetic mutations that are known to increase cancer risk. More...
26 Dec 2019
Image: The LH 750 hematology analyzer is equipped with advanced technologies with nucleated red blood cell (NRBC) enumeration and random access capabilities (Photo courtesy of Fameco Medical)

Hepatic Dysfunction and Coagulopathy Quantified in Fatal Dengue Fever

 Dengue fever (DF) is currently one of the most severe public health problems. Each year, an estimated 390 million dengue infections occur around the world. Clinical presentations of dengue are diverse and non-specific, often with unpredictable clinical progression and outcome. More...
24 Dec 2019
Image: Bone marrow film from a patient with myelodysplastic syndrome demonstrates small hypolobated megakaryocytes that are typical of the syndrome with isolated del(5q) (Photo courtesy of John P. Hunt, MD)

Distinct Myelodysplastic Syndrome Subtypes Identified by Genomic, Transcriptomic Analysis

 Myelodysplastic syndrome is a premalignant disease that affects myeloid cell. It is a precursor to acute myeloid leukemia, an aggressive blood cancer caused by the accumulation of immature blood cells. More...
23 Dec 2019
Image: Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality), compared with standard-issue red blood cells (Photo courtesy of The Children`s Hospital Westmead)

Fresh Red Blood Cells Transfusions No Better Than Older Ones

 Red blood-cell transfusions are commonly administered in critically ill children who have illnesses that increase the need for transfusion, such as trauma, cancer chemotherapy, major surgery with significant intraoperative bleeding, and conditions such as sickle cell disease and thalassemia. More...
23 Dec 2019
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.

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