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Clinical Chemistry

Image: In patients with psoriatic disease, cTnI may reflect the burden of atherosclerosis, independent of traditional cardiovascular risk factors (Photo courtesy of Cardiology Advisor)

Biomarkers Associated With Cardiovascular Outcomes in Psoriatic Patients

In patients with psoriatic disease (PsD), we determined whether cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) were associated with carotid plaque burden and the development of cardiovascular (CV) events independent of the Framingham Risk Score (FRS). More...
22 Mar 2022
Image: Low levels of folate (vitamin B9) in the blood may be linked to a heightened risk of dementia and death from any cause in older people (Photo courtesy of Regional Neurological Associates)

Serum Folate Deficiency in Older People Associated With Heightened Dementia

Low levels of folate (vitamin B9) in the blood may be linked to a heightened risk of dementia and death from any cause in older people, More...
21 Mar 2022
DIASOURCE (A Biovendor Company)
Image: The NanoSight NS300 utilizes the latest version of NanoSight’s particle characterization technology, Nanoparticle Tracking Analysis (NTA) (Photo courtesy of University of New South Wales)

Serum Extracellular Vesicle Arginase 1 Measured In T2DM

Serum extracellular vesicle (EV)-derived arginase 1 (ARG 1) plays a critical role in diabetes-associated endothelial dysfunction. This study was performed to determine the levels of serum EV-derived ARG 1 in T2DM and non-T2DM participants and to examine the association of serum EV-derived ARG 1 with T2DM incidence. More...
18 Mar 2022
Image: Synthetic biosensors can quickly assess cancer treatment (Photo courtesy of Pexels)

Biosensors Use Non-Invasive Urinalysis and AI for Quick Assessment of Cancer Treatment

A newly-developed system of synthetic biosensors will enable a patient and doctor to quickly learn if an immune checkpoint blockade (ICB) therapy is working through the use of non-invasive urinalysis and artificial intelligence (AI). More...
18 Mar 2022
Image: The HPLC model: LC-2050 series, three types of detector setup (UV, PDA, detector-less) are available to suit any analysis methods and aims (Photo courtesy of Shimadzu)

Proline-Specific Peptidase Activities in Plasma of Hospitalized COVID-19 Patients

COVID-19 patients experience several features of dysregulated immune system observed in sepsis. We previously showed a dysregulation of several proline-selective peptidases such as dipeptidyl peptidase 4 (DPP4), fibroblast activation protein alpha (FAP), prolyl oligopeptidase (PREP) and prolylcarboxypeptidase (PRCP) in sepsis. In this study, we investigated whether these peptidases are similarly dysregulated in hospitalized COVID-19 patients. More...
16 Mar 2022
Image: The Architect STAT Troponin-I assay is a 2-step chemiluminescent microparticle immunoassay designed to detect cardiac troponin I (cTnI) in serum and plasma using the ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott Diagnostics)

High-Sensitivity Troponin I Explored Post-Cardiac Surgery

Consensus recommendations regarding the threshold levels of cardiac troponin elevations for the definition of perioperative myocardial infarction and clinically important periprocedural myocardial injury in patients undergoing cardiac surgery range widely (from >10 times to ≥70 times the upper reference limit for the assay). Limited evidence is available to support these recommendations. More...
07 Mar 2022
Image: The STANDARD G6PD Test is a low-cost, simple device developed to guide treatment of patients with malaria and support malaria elimination programs (Photo courtesy of SD BIOSENSOR/PATH)

Repeatability and Reproducibility of a Handheld Quantitative G6PD Diagnostic

Novel treatment regimens for the radical cure of P. vivax malaria are more effective than current options but require prior quantitative G6PD testing. The reference method for quantitative G6PD measurement is spectrophotometry but, due to its operational characteristics, is not suitable for routine use. Furthermore, poor inter-laboratory reproducibility of spectrophotometry has prevented quantitative global definitions of G6PD deficiency. SD Biosensor (ROK) have developed a novel handheld “Biosensor” device (G6PD STANDARD), which measures G6PD activity within two minutes and has operational characteristics suited to point of care diagnosis. More...
03 Mar 2022
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