We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Randox Laboratories

Provides global diagnostic solutions for hospital laboratories, forensic laboratories, research laboratories, pharmac... read more Featured Products: More products

Download Mobile App




Biochemical Parameters Compared for Diabetic Ketoacidosis Severity

By LabMedica International staff writers
Posted on 19 Jan 2022
Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus characterized by hyperglycemia and ketoacidosis. More...
It can occur in both type 1 diabetes (T1DM) and type 2 (T2DM) diabetes patients under stress conditions.

Laboratory findings in DKA consist of hyperglycemia, high anion gap metabolic acidosis, and detection of serum ketone or urine ketone bodies. Three types of ketone bodies, acetoacetate, beta-hydroxybutyrate (BHB), and acetone, are produced in DKA. The ratio of BHB to acetoacetate in patients with DKA is increased by 10 times compared with the healthy population.

Endocrinologists at the Maharaj Nakorn Si Thammarat Hospital (Muang, Thailand) and their colleagues recruited 99 patients with type 1 or type 2 diabetes mellitus that were diagnosed with DKA between October 1, 2018 and September 30, 2020 into a prospective observational study. The inclusion criteria were: age > 18 years, diagnosed with DKA and admitted to the hospital, serum blood glucose ≥250 mg/dL and serum BHB ≥3 mmol/L, and venous blood pH < 7.3 or serum bicarbonate < 18 mmol/L.

Serum BHB was measured by an enzymatic method, the Ranbut assay, (Randox Laboratories Limited, Crumlin, UK). The test was linear for serum BHB at 0.1–5.75 mmol/L and had a correlation coefficient of r = 0.9954. Serum glucose, blood urea nitrogen (BUN), creatinine, serum lactate, and serum electrolytes were measured using a c501 module of the Cobas 6000 analyzer series (Roche Diagnostics, Rotkreuz, Switzerland).

The investigators reported a total of 99 diabetes patients were diagnosed with DKA (mean age 39.4 years, 63.4% female, 53.6% T2DM). while infection was the most common precipitating factor in T2DM (43.4%), non-compliance with treatment was the most common precipitating factor in T1DM (43.5%). The initial laboratories evaluation of patients did not significant differ between type1 and type2 diabetes. Serum BHB during treatment of DKA was significantly correlated with changes in serum bicarbonate, serum anion gap, and venous pH. The serum BHB levels corresponding to HCO3 levels for DKA severity were 4.5, 5.7, and 5.9 mmol/L in mild, moderate, and severe DKA, respectively. The serum BHB level of < 1 mmol/L had 73.7% sensitivity and 100% specificity to predict DKA resolution. Median time to resolution of DKA was 12 hours with an optimized BHB cut-off value of < 1 mmol/L. There were no significant difference in time to resolution of DKA in the patients with type 1 and type 2 diabetes.

The authors concluded there are no differences in DKA-related biochemical parameters between type 1 and type 2 diabetes patients. The present findings suggest that DKA should be assessed and treated similarly, regardless of its occurrence in type 1 or type 2 diabetes patients. The study was published on January 6, 2022 in the journal BMC Endocrine Disorders.

Related Links:
Maharaj Nakorn Si Thammarat Hospital
Randox Laboratories
Roche Diagnostics



Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Multilevel Whole Blood Calibrator Set
6PLUS1
New
Hepatitis A Rapid Test
Anti-HAV IgM Rapid Test Kit
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: Schematic overview of the deep learning-based circulating exosome analysis for lung cancer detection (Photo courtesy of Chuan Xu, Cheng Jiang)

Liquid Biopsy Approach to Transform Diagnosis, Monitoring and Treatment of Lung Cancer

Lung cancer continues to be a major contributor to cancer-related deaths globally, with its biological complexity and diverse regulatory processes making diagnosis and treatment particularly difficult.... Read more

Pathology

view channel
Image: The Aiforia Breast Cancer Grading AI solution is CE-IVD marked (Photo courtesy of Aiforia Technologies)

Clinical AI Solution for Automatic Breast Cancer Grading Improves Diagnostic Accuracy

Labs that use traditional image analysis methods often suffer from bottlenecks and delays. By digitizing their pathology practices, labs can streamline their work, allowing them to take on larger caseloads... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.