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Clinical Chemistry

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Diabetic Risk in Obesity Delineated by Metabolic Status

The simple anthropometric measure of body mass index does not always reflect the biological effects of excessive body fat on health, thus additional molecular characterizations of obese phenotypes are needed to assess the risk of developing subsequent metabolic conditions at an individual level.   More...
10 Nov 2015
Image: Histologic appearance of tendinosis tissue shows a characteristic pattern of fibroblasts and vascular, atypical, granulation-like tissue (Photo courtesy of Dr. Barry S. Kraushaar, MD).

High Cholesterol Linked to Risk of Tendinopathy

People with genetically determined very high cholesterol levels, as in familial hypercholesterolaemia, seem to be at greater risk of tendon pain, but it is not clear if those with lower, but still high levels might also be vulnerable to tendon injuries.   More...
03 Nov 2015
Image: The prototype microfluidic metabolite device (Photo courtesy of EPFL).

Miniaturized Device Monitors Blood Metabolites in ICU

A miniaturized microfluidic device could allow healthcare workers to monitor key metabolites in real time in intensive care units.  More...
03 Nov 2015
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Blood Test Rapidly Identifies Low Risk of Cardiac Event

A test that measures blood for the cardiac troponin protein, which is released by damaged heart cells, may help doctors rule out heart attack faster in patients with similar symptoms.  More...
21 Oct 2015

Blood Metabolites May Serve as Kidney Function Indicators

A nontargeted metabolomics approach in which gas and liquid chromatography were coupled to mass spectrometry was used to quantify 493 small molecules in human serum and relate them to changes in kidney function due to chronic kidney disease.  More...
19 Oct 2015
Image: Histopathology of an adrenal incidentaloma showing the pushing border between the adenoma and the surrounding parenchyma (arrows) (Photo courtesy of the Government of Western Australia).

Novel Urinary Biomarkers May Indicate Adrenal Cancer

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors.   More...
19 Oct 2015
Image: The Afinion C-reactive protein (CRP) Test Cartridge contains all reagents necessary for measurement of CRP in whole blood, serum or plasma (Photo courtesy of Alere).

Quick Test Minimizes Unnecessary Primary Care Antibiotic Prescribing

C-reactive protein is a biomarker in blood which indicates the presence of inflammation, and the amount of CRP in the body gives an indication of the severity of an infection. Low levels of CRP are indicative of viral or self-limiting bacterial infections, and high levels indicate serious infection.   More...
19 Oct 2015
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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