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Clinical Chemistry

Image: The Synergy HTX multi-mode microplate reader is a compact, affordable system for 6- to 384-well microplates and Take3 Micro-Volume Plates (Photo courtesy of BioTek).

Fluorimetric Assay Quantifies Galactocerebrosidase Activity in Dried Blood Spots

The lysosomal enzyme galactocerebrosidase hydrolyzes glycosidic bonds of several glycosphingolipids, including galactose from galactosylsphingosine (psychosine), and is essential to prevent the toxic accumulation of psychosine in the body. More...
29 Oct 2019
Image: The Lumipulse G600 II is a fully automated benchtop chemiluminescent enzyme immunoassay analyzer (Photo courtesy of Fujirebio Europe).

Fibroblast Growth Factor 23 Associated with Diabetic CV Risks

There is an association between higher levels of fibroblast growth factor 23 (FGF23), and greater cardiovascular and mortality risks for adults with type 2 diabetes and normal or mildly impaired kidney function. More...
26 Oct 2019
Image: A microscope image of thyroid cancer cells, specifically papillary thyroid carcinoma, or PTC (Photo courtesy of Wendong Yu/Baylor College of Medicine).

Metabolic Classification of Thyroid Nodules Uses MS Imaging

Fine-needle aspiration (FNA) biopsy is a well-established technique for diagnosis of suspicious thyroid lesions. However, histologic discrimination between malignant and benign thyroid nodules from FNA can be challenging. More...
26 Oct 2019
Image: The VACUETTE Venous K2EDTA blood collection tubes were found the most suitable for the pre-analytical conditions for serotonin assays (Photo courtesy of Greiner Bio-One).

Pre-Analytical Protocols Compared for Serotonin Quantification

Serotonin (5-hydroxytryptamine) is an important neurotransmitter and neuromodulator, which affects many neurophysiological processes, mood and cognition, regulates motility and sensibility in the bowel, and has an essential role in regulating blood pressure. More...
24 Oct 2019
Image: The PATHFAST compact benchtop automatic immunoassay analyzer (Photo courtesy of LSI Medience).

Presepsin Concentrations Correlate with Kidney Function Decline

Sepsis is an important public health problem with more than 750,000 patients reported yearly in the USA with similar figures in Europe. Sepsis continues to be a challenge for practitioners, as sepsis mortality rates are still high despite new antimicrobial and resuscitation agents. More...
24 Oct 2019
Image: The cobas 6500 urine analyzer series is a fully automated work area solution designed for laboratories that process 100 – 500 urine samples per day (Photo courtesy of Roche Diagnostics).

Automated Urine Analyzer And Components Evaluated

Urinalysis is a very common technique used in clinical practice, providing crucial information on the functioning of the kidneys and other organ systems, and aiding clinical decision-making in various diseases, such as diabetes, glomerulonephritis, and suspected urinary tract infections. More...
15 Oct 2019
Image: Abnormal serum hepatic enzymes and lipid levels are associated with glycemic control in patients with type 2 diabetes mellitus (Photo courtesy of SRL Diagnostics).

Liver Biomarkers Tied to Glycemic Control in Diabetes

As liver biomarkers serve as an effective indicator of liver injury in patients whom liver functions are somewhat above average. The abnormality of these markers acts as a worrying sign to the liver function. More...
10 Oct 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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