We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics- Hematology Division

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Admission HbA1c Levels Associated with Risk of Second Stroke in Diabetics

By LabMedica International staff writers
Posted on 18 Oct 2021
Print article
Image: The association between admission HbA1c and subsequent risk of composite vascular events, including stroke, myocardial infarction, and vascular death, in patients with acute ischemic stroke and diabetes has been reported (Photo courtesy of Diabetes.co.uk)
Image: The association between admission HbA1c and subsequent risk of composite vascular events, including stroke, myocardial infarction, and vascular death, in patients with acute ischemic stroke and diabetes has been reported (Photo courtesy of Diabetes.co.uk)
An ischemic attack is caused by a disruption in the blood supply to part of the brain and this disruption in blood supply results in a lack of oxygen to the brain. This can cause sudden symptoms similar to a stroke, such as speech and visual disturbance, and numbness or weakness in the face, arms and legs.

The formation of the sugar-hemoglobin linkage indicates the presence of excessive sugar in the bloodstream, often indicative of diabetes. Glycated hemoglobin (HbA1c) is of particular interest because it is easy to detect. HbA1c measured primarily to determine the three-month average blood sugar level and can be used as a diagnostic test for diabetes mellitus and as an assessment test for glycemic control in people with diabetes.

A team of Neurologists collaborating with the Seoul National University College of Medicine (Seoul, Korea) evaluated the association between admission HbA1c and subsequent risk of composite vascular events, including stroke, myocardial infarction, and vascular death, in patients with acute ischemic stroke and diabetes. The study involved 18,567 people with diabetes with a median age of 70 years. All participants were admitted to the hospital for an ischemic stroke. Upon admission, the team studied the HbA1c levels over the past two to three months before the stroke.

The investigators reported that of all participants, 1,437 (~8%) had a myocardial infarction (MI) or died from vascular disease within one year of starting the study, and 954 (5%) had another stroke. They found that people admitted to the hospital with HbA1c levels above the 6.8% to 7.0% range had an increased risk of having a vascular event, as well as having another stroke.

After adjusting for factors like age and sex, the team found that people’s risk for a MI or similar vascular diseases was 27% greater when they were admitted to the hospital with HbA1c levels >7.0%, compared with those admitted with HbA1c levels <6.5%. People’s risk for having another stroke was 28% greater when admitted to the hospital with HbA1c levels above 7.0%, compared with those below 6.5%. The influence of admission HbA1c level on the risk of composite vascular events was pronounced particularly among those in whom fasting glucose at admission was ≤130 mg/dL.

Moon-Ku Han, MD, PhD, a Neurologist and a senior author of the study, said, “We know that having diabetes may be associated with an increased risk of having a first stroke. But our results indicate that there is an optimal blood glucose level that may start to minimize the risk of having another stroke, myocardial infarction, or other vascular problems, and it’s right in the 6.8% to 7.0% range.”

The authors concluded that in patients with ischemic stroke and diabetes, the risks of composite vascular events were significantly associated with admission HbA1c. The optimal range of the admission HbA1c was below 6.8%–7.0%, and was different according to the ischemic stroke subtype. The study was published on September 29, 2021 in the journal Neurology.

Related Links:
Seoul National University College of Medicine

Gold Supplier
Fully Automated ELISA Workstation
EUROLabWorkstation ELISA
KRONUS Glutamic Acid Decarboxylase Autoantibody (GADAb) ELISA Assay Kit
Vented Safety Enclosures
VSE Balance Enclosures
Clinical Chemistry Reagents
SEKURE Clinical Chemistry Reagents

Print article



view channel
Image: Atellica Solution (Photo courtesy of Siemens Healthineers)

Siemens Introduces New Intelligent, Integrated IVD Solutions Virtually at EUROMEDLAB 2021

Siemens Healthineers (Erlangen, Germany) introduced new intelligent, integrated IVD solutions virtually at the XXIV IFCCEFLM European Congress of Clinical Chemistry and Laboratory Medicine (EuroMedLab... Read more


view channel
Image: The Luminex 200 Instrument System sets the standard for multiplexing, providing the ability to perform up to 100 different tests in a single reaction volume on a flow cytometry-based platform (Photo courtesy of Luminex Corp)

Inflammatory Cytokines Measured in Infants Born to Preterm Preeclamptic Mothers

Preeclampsia is both a vascular and inflammatory disorder. The pathophysiology of preeclampsia is complex and rooted in the interplay between maternal and placental factors with the key characteristics... Read more


view channel
Image: The sciREADER CL2 enables high quality digital colorimetric imaging of various support formats (Photo courtesy of SCIENION)

Multiplex Immunoassay Developed for Confirmation and Typing of HTLV Infections

Human T-Cell Lymphotropic Viruses (HTLV) type 1 and type 2 account for an estimated five to 10 million infections worldwide and are transmitted through breast feeding, sexual contacts and contaminated... Read more


view channel
Image: The Ventana BenchMark Ultra autostainer is for cancer diagnostics with automation and the test menu include IHC, ISH, and FITC tests (Photo courtesy of Ventana Medical System)

Specific Biomarker Investigated for Triple-Negative Breast Cancer Diagnosis

Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression and comprises a heterogeneous... Read more


view channel
Image: PKeye Workflow Monitor System (Photo courtesy of PerkinElmer, Inc.)

PerkinElmer’s New Cloud-Based Platform Enables Laboratory Personnel to Remotely Manage Its Instruments in Real-Time

PerkinElmer, Inc. (Waltham, MA; USA) has launched its PKeye Workflow Monitor, a cloud-based platform enabling laboratory personnel to remotely manage and monitor their PerkinElmer instruments and workflows... Read more


view channel

Global Lateral Flow Assay Market to Reach Nearly USD 6.5 Billion by 2031 Due to Surge in Demand for Rapid POC Testing

The global lateral flow assay market is projected to grow at a CAGR of around 5% from USD 3.7 billion in 2020 to over USD 6.4 billion by 2031, driven by the growing adoption of home-based lateral flow... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.